The Hows and Whys

Laurence D. Hurst, Csaba Pál

Research output: Contribution to journalArticlepeer-review


In the majority of organisms, most gene knockouts have little or no affect on viability. Does this mean that most genes are dispensable to an organism? What are the underlying mechanisms of dispensability and why did dispensability evolve?

Original languageEnglish
Pages (from-to)30-34
Number of pages5
JournalThe Biochemist
Issue number1
Publication statusPublished - 1 Feb 2009


  • enzymes
  • gene knockouts
  • isozymes
  • mutation rates
  • paralogs

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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