The histological features of anteromedial gonarthrosis - the comparison of two grading systems in a human phenotype of osteoarthritis

R. Rout, S. McDonnell, R. Benson, N. Athanasou, A. Carr, H. Doll, H. S. Gill, D. W. Murray, P. A. Hulley, A. J. Price

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Anteromedial Gonarthrosis (AMG) displays a well recognised pattern of cartilage damage on the medial tibial plateau. Anteriorly there is a full thickness cartilage defect, with transition to a partial thickness defect, becoming full thickness cartilage in the posterior third of the tibial plateau. The retained posterior cartilage is macroscopically normal. This study characterises the histological changes of AMG and examines the usefulness of two histological assessment tools. Sixteen unicompartmental resection specimens of patients with primary AMG were assessed. Samples were stained with Haematoxylin and Eosin and Safranin-O stains and scored using the modified Mankin grade, and the OOCHAS assessment tool. Each specimen was assessed at five regions along the antero-posterior axis starting from the exposed bone to the region of macroscopically normal cartilage. From anterior to posterior the staining showed a consistent increase in structural integrity and cellularity of the cartilage, matched by a qualitative increase in GAG content. Mean modified Mankin and OOCHAS scores showed a progressive decrease in grade (p
Original languageEnglish
Pages (from-to)172-176
Number of pages5
JournalThe Knee
Volume18
Issue number3
DOIs
Publication statusPublished - 2011

Fingerprint

Osteoarthritis
Cartilage
Phenotype
Hematoxylin
Eosine Yellowish-(YS)
Coloring Agents
Staining and Labeling
Bone and Bones

Cite this

The histological features of anteromedial gonarthrosis - the comparison of two grading systems in a human phenotype of osteoarthritis. / Rout, R.; McDonnell, S.; Benson, R.; Athanasou, N.; Carr, A.; Doll, H.; Gill, H. S.; Murray, D. W.; Hulley, P. A.; Price, A. J.

In: The Knee, Vol. 18, No. 3, 2011, p. 172-176.

Research output: Contribution to journalArticle

Rout, R, McDonnell, S, Benson, R, Athanasou, N, Carr, A, Doll, H, Gill, HS, Murray, DW, Hulley, PA & Price, AJ 2011, 'The histological features of anteromedial gonarthrosis - the comparison of two grading systems in a human phenotype of osteoarthritis', The Knee, vol. 18, no. 3, pp. 172-176. https://doi.org/10.1016/j.knee.2010.04.010
Rout, R. ; McDonnell, S. ; Benson, R. ; Athanasou, N. ; Carr, A. ; Doll, H. ; Gill, H. S. ; Murray, D. W. ; Hulley, P. A. ; Price, A. J. / The histological features of anteromedial gonarthrosis - the comparison of two grading systems in a human phenotype of osteoarthritis. In: The Knee. 2011 ; Vol. 18, No. 3. pp. 172-176.
@article{15de72900e7d46a59825855ca658b934,
title = "The histological features of anteromedial gonarthrosis - the comparison of two grading systems in a human phenotype of osteoarthritis",
abstract = "Anteromedial Gonarthrosis (AMG) displays a well recognised pattern of cartilage damage on the medial tibial plateau. Anteriorly there is a full thickness cartilage defect, with transition to a partial thickness defect, becoming full thickness cartilage in the posterior third of the tibial plateau. The retained posterior cartilage is macroscopically normal. This study characterises the histological changes of AMG and examines the usefulness of two histological assessment tools. Sixteen unicompartmental resection specimens of patients with primary AMG were assessed. Samples were stained with Haematoxylin and Eosin and Safranin-O stains and scored using the modified Mankin grade, and the OOCHAS assessment tool. Each specimen was assessed at five regions along the antero-posterior axis starting from the exposed bone to the region of macroscopically normal cartilage. From anterior to posterior the staining showed a consistent increase in structural integrity and cellularity of the cartilage, matched by a qualitative increase in GAG content. Mean modified Mankin and OOCHAS scores showed a progressive decrease in grade (p",
author = "R. Rout and S. McDonnell and R. Benson and N. Athanasou and A. Carr and H. Doll and Gill, {H. S.} and Murray, {D. W.} and Hulley, {P. A.} and Price, {A. J.}",
note = "Rout, Rajesh McDonnell, Stephen Benson, Richard Athanasou, Nicholas Carr, Andrew Doll, Helen Gill, Harinderjit S Murray, David W Hulley, Philippa A Price, Andrew J Netherlands The Knee Knee. 2011 Jun;18(3):172-6. Epub 2010 May 31.",
year = "2011",
doi = "10.1016/j.knee.2010.04.010",
language = "English",
volume = "18",
pages = "172--176",
journal = "The Knee",
issn = "0968-0160",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - The histological features of anteromedial gonarthrosis - the comparison of two grading systems in a human phenotype of osteoarthritis

AU - Rout, R.

AU - McDonnell, S.

AU - Benson, R.

AU - Athanasou, N.

AU - Carr, A.

AU - Doll, H.

AU - Gill, H. S.

AU - Murray, D. W.

AU - Hulley, P. A.

AU - Price, A. J.

N1 - Rout, Rajesh McDonnell, Stephen Benson, Richard Athanasou, Nicholas Carr, Andrew Doll, Helen Gill, Harinderjit S Murray, David W Hulley, Philippa A Price, Andrew J Netherlands The Knee Knee. 2011 Jun;18(3):172-6. Epub 2010 May 31.

PY - 2011

Y1 - 2011

N2 - Anteromedial Gonarthrosis (AMG) displays a well recognised pattern of cartilage damage on the medial tibial plateau. Anteriorly there is a full thickness cartilage defect, with transition to a partial thickness defect, becoming full thickness cartilage in the posterior third of the tibial plateau. The retained posterior cartilage is macroscopically normal. This study characterises the histological changes of AMG and examines the usefulness of two histological assessment tools. Sixteen unicompartmental resection specimens of patients with primary AMG were assessed. Samples were stained with Haematoxylin and Eosin and Safranin-O stains and scored using the modified Mankin grade, and the OOCHAS assessment tool. Each specimen was assessed at five regions along the antero-posterior axis starting from the exposed bone to the region of macroscopically normal cartilage. From anterior to posterior the staining showed a consistent increase in structural integrity and cellularity of the cartilage, matched by a qualitative increase in GAG content. Mean modified Mankin and OOCHAS scores showed a progressive decrease in grade (p

AB - Anteromedial Gonarthrosis (AMG) displays a well recognised pattern of cartilage damage on the medial tibial plateau. Anteriorly there is a full thickness cartilage defect, with transition to a partial thickness defect, becoming full thickness cartilage in the posterior third of the tibial plateau. The retained posterior cartilage is macroscopically normal. This study characterises the histological changes of AMG and examines the usefulness of two histological assessment tools. Sixteen unicompartmental resection specimens of patients with primary AMG were assessed. Samples were stained with Haematoxylin and Eosin and Safranin-O stains and scored using the modified Mankin grade, and the OOCHAS assessment tool. Each specimen was assessed at five regions along the antero-posterior axis starting from the exposed bone to the region of macroscopically normal cartilage. From anterior to posterior the staining showed a consistent increase in structural integrity and cellularity of the cartilage, matched by a qualitative increase in GAG content. Mean modified Mankin and OOCHAS scores showed a progressive decrease in grade (p

UR - http://www.scopus.com/inward/record.url?scp=79955029458&partnerID=8YFLogxK

UR - http://dx.doi.org/10.1016/j.knee.2010.04.010

UR - http://www.ncbi.nlm.nih.gov/pubmed/20570154

U2 - 10.1016/j.knee.2010.04.010

DO - 10.1016/j.knee.2010.04.010

M3 - Article

VL - 18

SP - 172

EP - 176

JO - The Knee

JF - The Knee

SN - 0968-0160

IS - 3

ER -