TY - JOUR
T1 - The genetic architecture of the human cerebral cortex
AU - Alzheimer’s Disease Neuroimaging Initiative
AU - Grasby, Katrina L
AU - Jahanshad, Neda
AU - Painter, Jodie N
AU - Colodro-Conde, Lucía
AU - Bralten, Janita
AU - Hibar, Derrek P
AU - Lind, Penelope A
AU - Pizzagalli, Fabrizio
AU - Ching, Christopher R K
AU - McMahon, Mary Agnes B
AU - Shatokhina, Natalia
AU - Zsembik, Leo C P
AU - Thomopoulos, Sophia I
AU - Zhu, Alyssa H
AU - Strike, Lachlan T
AU - Agartz, Ingrid
AU - Alhusaini, Saud
AU - Almeida, Marcio A A
AU - Alnæs, Dag
AU - Amlien, Inge K
AU - Andersson, Micael
AU - Ard, Tyler
AU - Armstrong, Nicola J
AU - Ashley-Koch, Allison
AU - Atkins, Joshua R
AU - Bernard, Manon
AU - Brouwer, Rachel M
AU - Buimer, Elizabeth E L
AU - Bülow, Robin
AU - Bürger, Christian
AU - Cannon, Dara M
AU - Chakravarty, Mallar
AU - Cheung, Joshua W
AU - Couvy-Duchesne, Baptiste
AU - Dale, Anders M
AU - Dalvie, Shareefa
AU - de Araujo, Tânia K
AU - de Zubicaray, Greig I
AU - de Zwarte, Sonja M C
AU - den Braber, Anouk
AU - Doan, Nhat Trung
AU - Dohm, Katharina
AU - Ehrlich, Stefan
AU - Engelbrecht, Hannah-Ruth
AU - Erk, Susanne
AU - Fan, Chun Chieh
AU - Fedko, Iryna O
AU - Foley, Sonya F
AU - Ford, Judith M
AU - Walton, Esther
AU - Lancaster, Thomas M.
N1 - Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
PY - 2020/3/20
Y1 - 2020/3/20
N2 - The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.
AB - The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.
UR - http://www.scopus.com/inward/record.url?scp=85082081461&partnerID=8YFLogxK
U2 - 10.1126/science.aay6690
DO - 10.1126/science.aay6690
M3 - Article
C2 - 32193296
VL - 367
JO - Science
JF - Science
SN - 0036-8075
IS - 6484
M1 - eaay6990
ER -
