The evolution of sex-specific dominance in response to sexually antagonistic selection

Hamish G. Spencer, Nicholas K. Priest

Research output: Contribution to journalArticle

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Abstract

Arguments about the evolutionary modification of genetic dominance have a long history in genetics, dating back more than 100 years. Mathematical investigations have shown that modifiers of the level of dominance at the locus of interest can spread at a reasonable rate only if heterozygotes at that locus are common. One hitherto neglected scenario is that of sexually antagonistic selection, which not only is ubiquitous in sexual species but also can generate stable high frequencies of heterozygotes that would appear to facilitate the spread of such modifiers. Here we present a mathematical model that shows that sexually specific dominance modification is a potential outcome of sexually antagonistic selection. Our model predicts that loci with higher levels of sexual conflict should exhibit greater differentiation between males and females in levels of dominance and that the strength of antagonistic selection experienced by one sex should be proportional to the level of dominance modification. We show that evidence from the literature is consistent with these predictions but suggest that empiricists should be alert to the possibility of there being numerous cases of sex-specific dominance. Further, in order to determine the significance of sexual conflict in the evolution of dominance, we need improved measures of sexual conflict and better characterization of loci that modify dominance of genes with sexually antagonistic fitness effects.
LanguageEnglish
Article number10.1086/685827
Pages658-666
Number of pages9
JournalThe American Naturalist
Volume187
Issue number5
Early online date22 Mar 2016
DOIs
StatusPublished - May 2016

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Genes
Mathematical models
Genetics

Keywords

  • Fisher; Wright; genetic dominance; mathematical model; modification of dominance; sexual conflict

ASJC Scopus subject areas

  • Materials Science(all)

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The evolution of sex-specific dominance in response to sexually antagonistic selection. / Spencer, Hamish G.; Priest, Nicholas K.

In: The American Naturalist, Vol. 187, No. 5, 10.1086/685827, 05.2016, p. 658-666.

Research output: Contribution to journalArticle

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