The evolution of isochores

A Eyre-Walker; L D Hurst

doi:10.1038/35080577

The evolution of isochores

A Eyre-Walker
, L D Hurst

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

346 Citations (SciVal)

Abstract

One of the most striking features of mammalian chromosomes is the variation in G+C content that occurs over scales of hundreds of kilobases to megabases, the so-called 'isochore' structure of the human genome. This variation in base composition affects both coding and non-coding sequences and seems to reflect a fundamental level of genome organization. However, although we have known about isochores for over 25 years, we still have a poor understanding of why they exist. In this article, we review the current evidence for the three main hypotheses.

Original language	English
Pages (from-to)	549-555
Number of pages	7
Journal	Nature Reviews Genetics
Volume	2
Issue number	7
DOIs	https://doi.org/10.1038/35080577
Publication status	Published - 2001

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ID number: ISI:000169681600015

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10.1038/35080577

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AB - One of the most striking features of mammalian chromosomes is the variation in G+C content that occurs over scales of hundreds of kilobases to megabases, the so-called 'isochore' structure of the human genome. This variation in base composition affects both coding and non-coding sequences and seems to reflect a fundamental level of genome organization. However, although we have known about isochores for over 25 years, we still have a poor understanding of why they exist. In this article, we review the current evidence for the three main hypotheses.

U2 - 10.1038/35080577

DO - 10.1038/35080577

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EP - 555

JO - Nature Reviews Genetics

JF - Nature Reviews Genetics

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The evolution of isochores

Abstract

Bibliographical note

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