Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 119-128 |
| Number of pages | 10 |
| Journal | Heredity |
| Volume | 113 |
| Issue number | 2 |
| Early online date | 23 Apr 2014 |
| DOIs | |
| Publication status | Published - Aug 2014 |
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The evolution of genomic imprinting : Theories, predictions and empirical tests. / Patten, M M; Ross, L; Curley, J P; Queller, D C; Bonduriansky, R; Wolf, J B.
In: Heredity, Vol. 113, No. 2, 08.2014, p. 119-128.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The evolution of genomic imprinting
T2 - Theories, predictions and empirical tests
AU - Patten, M M
AU - Ross, L
AU - Curley, J P
AU - Queller, D C
AU - Bonduriansky, R
AU - Wolf, J B
PY - 2014/8
Y1 - 2014/8
N2 - The epigenetic phenomenon of genomic imprinting has motivated the development of numerous theories for its evolutionary origins and genomic distribution. In this review, we examine the three theories that have best withstood theoretical and empirical scrutiny. These are: Haig and colleagues' kinship theory; Day and Bonduriansky's sexual antagonism theory; and Wolf and Hager's maternal-offspring coadaptation theory. These theories have fundamentally different perspectives on the adaptive significance of imprinting. The kinship theory views imprinting as a mechanism to change gene dosage, with imprinting evolving because of the differential effect that gene dosage has on the fitness of matrilineal and patrilineal relatives. The sexual antagonism and maternal-offspring coadaptation theories view genomic imprinting as a mechanism to modify the resemblance of an individual to its two parents, with imprinting evolving to increase the probability of expressing the fitter of the two alleles at a locus. In an effort to stimulate further empirical work on the topic, we carefully detail the logic and assumptions of all three theories, clarify the specific predictions of each and suggest tests to discriminate between these alternative theories for why particular genes are imprinted.
AB - The epigenetic phenomenon of genomic imprinting has motivated the development of numerous theories for its evolutionary origins and genomic distribution. In this review, we examine the three theories that have best withstood theoretical and empirical scrutiny. These are: Haig and colleagues' kinship theory; Day and Bonduriansky's sexual antagonism theory; and Wolf and Hager's maternal-offspring coadaptation theory. These theories have fundamentally different perspectives on the adaptive significance of imprinting. The kinship theory views imprinting as a mechanism to change gene dosage, with imprinting evolving because of the differential effect that gene dosage has on the fitness of matrilineal and patrilineal relatives. The sexual antagonism and maternal-offspring coadaptation theories view genomic imprinting as a mechanism to modify the resemblance of an individual to its two parents, with imprinting evolving to increase the probability of expressing the fitter of the two alleles at a locus. In an effort to stimulate further empirical work on the topic, we carefully detail the logic and assumptions of all three theories, clarify the specific predictions of each and suggest tests to discriminate between these alternative theories for why particular genes are imprinted.
UR - http://www.scopus.com/inward/record.url?scp=84904470794&partnerID=8YFLogxK
UR - http://dx.doi.org/10.1038/hdy.2014.29
U2 - 10.1038/hdy.2014.29
DO - 10.1038/hdy.2014.29
M3 - Article
VL - 113
SP - 119
EP - 128
JO - Heredity
JF - Heredity
SN - 0018-067X
IS - 2
ER -