The estimation of diffusion coefficients using the rotating diffusion cell

The rotating diffusion cell developed by Albery et al. (1976) has been used to estimate the diffusion coefficients of two esters of nicotinic acid in a selection of organic barriers. It is shown that the diffusion coefficients of these esters in some of the systems investigated are comparable to their values in the epidermis of human skin. The rotating diffusion cell is therefore proposed as a possible in vitro method for studying the percutaneous absorption of certain drugs.