The enigma of phosphoinositides and their derivatives: Their role in regulation of subcellular compartment morphology

Banafshé Larijani; Lior Pytowski; David J. Vaux

doi:10.1016/j.bbamem.2021.183780

The enigma of phosphoinositides and their derivatives: Their role in regulation of subcellular compartment morphology

Banafshé Larijani
, Lior Pytowski
, David J. Vaux

University of Oxford

Research output: Contribution to journal › Review article › peer-review

5 Citations (SciVal)

Abstract

The general segregation of a molecular class, lipids, from the pathways of cellular communication, via endo-membranes, has resulted in the over-simplification and misconceptions in deciphering cell signalling mechanisms. Mechanisms in signal transduction and protein activation require targeting of proteins to membranous compartments with a specific localised morphology and dynamics that are dependent on their lipid composition. Many posttranslational events define cellular behaviours and without the active role of membranous compartments these events lead to various dysregulations of the signalling pathways. We summarise the key findings, using tools such as the rapalogue dimerisation, in the structural roles and signalling of the inter-related phosphoinositide lipids and their derivative, diacylglycerol, in the regulation of nuclear envelope biogenesis and other subcellular compartments such as the nucleoplasmic reticulum.

Original language	English
Article number	183780
Journal	Biochimica Et Biophysica Acta-Biomembranes
Volume	1864
Issue number	1
Early online date	20 Sept 2021
DOIs	https://doi.org/10.1016/j.bbamem.2021.183780
Publication status	Published - 1 Feb 2022

Funding

The decades of collaboration and discussions with Dominic L. Poccia (Amherst College) have led to our advances and the pioneering work in the mechanisms involved in the nuclear envelope assembly. We are eternally grateful to him. We would like to thank Peter J. Parker (The Francis Crick Institute), Erick J. Dufourc (CNRS and CBMN-Bordeaux), Lucy Collinson (The Francis Crick Institute), the late Michael Wakelam (Former Director of Babraham Institute), Kenton Arkill (University of Nottingham), and members of Cell Biophysics Laboratory (London, Bilbao and Bath) for their fruitful collaborations and contributions in the research presented in this manuscript. The results described here were funded mainly by core funding from Cancer Research UK. and The Basque Government Grant (IT1270-19) contribution was mainly work from Dazzoni et al. publications 2020). Prof Banafshe Larijani reports financial support and administrative support were provided by Cancer Research UK.

Keywords

CLEM
Membrane fusion
Nuclear envelope
Nucleoplasmic reticula
Phosphoinositides
Rapalogue dimerisation tool

ASJC Scopus subject areas

Biophysics
Biochemistry
Cell Biology

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10.1016/j.bbamem.2021.183780

Cite this

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abstract = "The general segregation of a molecular class, lipids, from the pathways of cellular communication, via endo-membranes, has resulted in the over-simplification and misconceptions in deciphering cell signalling mechanisms. Mechanisms in signal transduction and protein activation require targeting of proteins to membranous compartments with a specific localised morphology and dynamics that are dependent on their lipid composition. Many posttranslational events define cellular behaviours and without the active role of membranous compartments these events lead to various dysregulations of the signalling pathways. We summarise the key findings, using tools such as the rapalogue dimerisation, in the structural roles and signalling of the inter-related phosphoinositide lipids and their derivative, diacylglycerol, in the regulation of nuclear envelope biogenesis and other subcellular compartments such as the nucleoplasmic reticulum.",

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N2 - The general segregation of a molecular class, lipids, from the pathways of cellular communication, via endo-membranes, has resulted in the over-simplification and misconceptions in deciphering cell signalling mechanisms. Mechanisms in signal transduction and protein activation require targeting of proteins to membranous compartments with a specific localised morphology and dynamics that are dependent on their lipid composition. Many posttranslational events define cellular behaviours and without the active role of membranous compartments these events lead to various dysregulations of the signalling pathways. We summarise the key findings, using tools such as the rapalogue dimerisation, in the structural roles and signalling of the inter-related phosphoinositide lipids and their derivative, diacylglycerol, in the regulation of nuclear envelope biogenesis and other subcellular compartments such as the nucleoplasmic reticulum.

AB - The general segregation of a molecular class, lipids, from the pathways of cellular communication, via endo-membranes, has resulted in the over-simplification and misconceptions in deciphering cell signalling mechanisms. Mechanisms in signal transduction and protein activation require targeting of proteins to membranous compartments with a specific localised morphology and dynamics that are dependent on their lipid composition. Many posttranslational events define cellular behaviours and without the active role of membranous compartments these events lead to various dysregulations of the signalling pathways. We summarise the key findings, using tools such as the rapalogue dimerisation, in the structural roles and signalling of the inter-related phosphoinositide lipids and their derivative, diacylglycerol, in the regulation of nuclear envelope biogenesis and other subcellular compartments such as the nucleoplasmic reticulum.

KW - CLEM

KW - Membrane fusion

KW - Nuclear envelope

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KW - Phosphoinositides

KW - Rapalogue dimerisation tool

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The enigma of phosphoinositides and their derivatives: Their role in regulation of subcellular compartment morphology

Abstract

Funding

Keywords

ASJC Scopus subject areas

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