The enigma of phosphoinositides and their derivatives: Their role in regulation of subcellular compartment morphology

Banafshé Larijani, Lior Pytowski, David J. Vaux

Research output: Contribution to journalArticlepeer-review

Abstract

The general segregation of a molecular class, lipids, from the pathways of cellular communication, via endo-membranes, has resulted in the over-simplification and misconceptions in deciphering cell signalling mechanisms. Mechanisms in signal transduction and protein activation require targeting of proteins to membranous compartments with a specific localised morphology and dynamics that are dependent on their lipid composition. Many posttranslational events define cellular behaviours and without the active role of membranous compartments these events lead to various dysregulations of the signalling pathways. We summarise the key findings, using tools such as the rapalogue dimerisation, in the structural roles and signalling of the inter-related phosphoinositide lipids and their derivative, diacylglycerol, in the regulation of nuclear envelope biogenesis and other subcellular compartments such as the nucleoplasmic reticulum.
Original languageEnglish
Article number183780
JournalBiochimica Et Biophysica Acta-Biomembranes
Volume1864
Issue number1
Early online date20 Sep 2021
DOIs
Publication statusE-pub ahead of print - 20 Sep 2021

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