The emerging importance of ultradian glucocorticoid rhythms within metabolic pathology

Benjamin P. Flynn; Becky L. Conway-Campbell; Stafford L. Lightman

doi:10.1016/j.ando.2018.03.003

The emerging importance of ultradian glucocorticoid rhythms within metabolic pathology

Benjamin P. Flynn, Becky L. Conway-Campbell, Stafford L. Lightman

Department of Life Sciences

Research output: Contribution to journal › Article

7 Citations (SciVal)

Abstract

Glucocorticoid (GC) hormones play significant roles within homeostasis and the chrono-dynamics of their regulatory role has become increasingly recognised within dysregulated GC pathology, particularly with metabolic phenotypes. Within this article, we will discuss the relevance of the ultradian homeostatic rhythm, how its dysregulation effects glucocorticoid receptor and RNA polymeraseII recruitment and may play a significant role within aberrant metabolic action.

Original language	English
Pages (from-to)	112-114
Number of pages	3
Journal	Annales d'Endocrinologie
Volume	79
Issue number	3
Early online date	5 Apr 2018
DOIs	https://doi.org/10.1016/j.ando.2018.03.003
Publication status	Published - 1 Jun 2018

Keywords

Glucocorticoid receptor
Glucocorticoids
Metabolism
RNA polymeraseII
Synthetic steroids
Ultradian

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10.1016/j.ando.2018.03.003Licence: CC BY

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abstract = "Glucocorticoid (GC) hormones play significant roles within homeostasis and the chrono-dynamics of their regulatory role has become increasingly recognised within dysregulated GC pathology, particularly with metabolic phenotypes. Within this article, we will discuss the relevance of the ultradian homeostatic rhythm, how its dysregulation effects glucocorticoid receptor and RNA polymeraseII recruitment and may play a significant role within aberrant metabolic action.",

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AB - Glucocorticoid (GC) hormones play significant roles within homeostasis and the chrono-dynamics of their regulatory role has become increasingly recognised within dysregulated GC pathology, particularly with metabolic phenotypes. Within this article, we will discuss the relevance of the ultradian homeostatic rhythm, how its dysregulation effects glucocorticoid receptor and RNA polymeraseII recruitment and may play a significant role within aberrant metabolic action.

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KW - Glucocorticoids

KW - Metabolism

KW - RNA polymeraseII

KW - Synthetic steroids

KW - Ultradian

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SN - 0003-4266

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The emerging importance of ultradian glucocorticoid rhythms within metabolic pathology

Abstract

Keywords

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