The effects of different forms of daily exercise on metabolic function following short-term overfeeding and reduced physical activity in healthy young men:study protocol for a randomised controlled trial

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Abstract

Background:Short-term overfeeding combined with reduced physical activity impairs metabolic function and alters the expression of key genes within adipose tissue. We have shown that daily vigorous-intensity running can prevent these changes independent of any net effect on energy imbalance. However, which type, intensity and/or duration of exercise best achieves these benefits remains to be ascertained. Methods/design:Forty-eight healthy young men will be recruited and randomly allocated to one of four experimental conditions for 1 week: (1) to ingest 50% more energy than normal by over-consuming their habitual diet whilst simultaneously restricting their physical activity below 4000 steps day−1(i.e. energy surplus; SUR group);(2) the same regimen but with a daily 45-min bout of vigorous-intensity arm crank ergometry at 70% of maximum oxygen uptake (SUR + ARM group); (3) the same regimen but with a daily 45-min bout of moderate-intensity treadmill walking at 50% of maximum oxygen uptake (SUR + MOD group); (4) the same regimen but with the addition of intermittent short bouts of walking during waking hours (SUR + BREAKS group). Critically, all exercise groups will receive additional dietary energy intake to account for the energy expended by exercise,thus maintaining a matched energy surplus. At baseline and follow-up, fasted blood samples, abdominal subcutaneous adipose tissue and skeletal muscle biopsies will be obtained and oral glucose tolerance tests conducted. Discussion:This study will establish the impact of different forms of daily exercise on metabolic function at the whole-body level as well as within adipose tissue and skeletal muscle in the context of a standardised energy surplus.Trial registration:ISRCTN,ISRCTN18311163. Registered on 24 June 2015. Keywords:Exercise, Overfeeding, Reduced physical activity, Arm crank, Breaking sitting, Moderate-intensity exercise,Metabolism, Adipose tissue, Skeletal muscle and energy imbalance
LanguageEnglish
Article number199
Number of pages9
JournalTrials
Volume19
Issue number1
DOIs
StatusPublished - 27 Mar 2018

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Randomized Controlled Trials
Exercise
Adipose Tissue
Skeletal Muscle
Walking
Abdominal Subcutaneous Fat
Oxygen
Ergometry
Glucose Tolerance Test
Energy Intake
Running
Diet
Biopsy
Gene Expression

Keywords

  • Exercise
  • Overfeeding
  • Reduced physical activity
  • Arm crank
  • Breaking sitting
  • Moderate-intensity exercise
  • Metabolism
  • Adipose tissue
  • Skeletal muscle
  • energy imbalance

Cite this

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title = "The effects of different forms of daily exercise on metabolic function following short-term overfeeding and reduced physical activity in healthy young men:study protocol for a randomised controlled trial",
abstract = "Background:Short-term overfeeding combined with reduced physical activity impairs metabolic function and alters the expression of key genes within adipose tissue. We have shown that daily vigorous-intensity running can prevent these changes independent of any net effect on energy imbalance. However, which type, intensity and/or duration of exercise best achieves these benefits remains to be ascertained. Methods/design:Forty-eight healthy young men will be recruited and randomly allocated to one of four experimental conditions for 1 week: (1) to ingest 50{\%} more energy than normal by over-consuming their habitual diet whilst simultaneously restricting their physical activity below 4000 steps day−1(i.e. energy surplus; SUR group);(2) the same regimen but with a daily 45-min bout of vigorous-intensity arm crank ergometry at 70{\%} of maximum oxygen uptake (SUR + ARM group); (3) the same regimen but with a daily 45-min bout of moderate-intensity treadmill walking at 50{\%} of maximum oxygen uptake (SUR + MOD group); (4) the same regimen but with the addition of intermittent short bouts of walking during waking hours (SUR + BREAKS group). Critically, all exercise groups will receive additional dietary energy intake to account for the energy expended by exercise,thus maintaining a matched energy surplus. At baseline and follow-up, fasted blood samples, abdominal subcutaneous adipose tissue and skeletal muscle biopsies will be obtained and oral glucose tolerance tests conducted. Discussion:This study will establish the impact of different forms of daily exercise on metabolic function at the whole-body level as well as within adipose tissue and skeletal muscle in the context of a standardised energy surplus.Trial registration:ISRCTN,ISRCTN18311163. Registered on 24 June 2015. Keywords:Exercise, Overfeeding, Reduced physical activity, Arm crank, Breaking sitting, Moderate-intensity exercise,Metabolism, Adipose tissue, Skeletal muscle and energy imbalance",
keywords = "Exercise, Overfeeding, Reduced physical activity, Arm crank, Breaking sitting, Moderate-intensity exercise, Metabolism, Adipose tissue, Skeletal muscle, energy imbalance",
author = "Jean-Philippe Walhin and Yung-Chih Chen and Aaron Hengist and James Bilzon and James Betts and Dylan Thompson",
year = "2018",
month = "3",
day = "27",
doi = "10.1186/s13063-018-2579-6",
language = "English",
volume = "19",
journal = "Trials",
issn = "1745-6215",
publisher = "BioMed Central",
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TY - JOUR

T1 - The effects of different forms of daily exercise on metabolic function following short-term overfeeding and reduced physical activity in healthy young men:study protocol for a randomised controlled trial

AU - Walhin, Jean-Philippe

AU - Chen, Yung-Chih

AU - Hengist, Aaron

AU - Bilzon, James

AU - Betts, James

AU - Thompson, Dylan

PY - 2018/3/27

Y1 - 2018/3/27

N2 - Background:Short-term overfeeding combined with reduced physical activity impairs metabolic function and alters the expression of key genes within adipose tissue. We have shown that daily vigorous-intensity running can prevent these changes independent of any net effect on energy imbalance. However, which type, intensity and/or duration of exercise best achieves these benefits remains to be ascertained. Methods/design:Forty-eight healthy young men will be recruited and randomly allocated to one of four experimental conditions for 1 week: (1) to ingest 50% more energy than normal by over-consuming their habitual diet whilst simultaneously restricting their physical activity below 4000 steps day−1(i.e. energy surplus; SUR group);(2) the same regimen but with a daily 45-min bout of vigorous-intensity arm crank ergometry at 70% of maximum oxygen uptake (SUR + ARM group); (3) the same regimen but with a daily 45-min bout of moderate-intensity treadmill walking at 50% of maximum oxygen uptake (SUR + MOD group); (4) the same regimen but with the addition of intermittent short bouts of walking during waking hours (SUR + BREAKS group). Critically, all exercise groups will receive additional dietary energy intake to account for the energy expended by exercise,thus maintaining a matched energy surplus. At baseline and follow-up, fasted blood samples, abdominal subcutaneous adipose tissue and skeletal muscle biopsies will be obtained and oral glucose tolerance tests conducted. Discussion:This study will establish the impact of different forms of daily exercise on metabolic function at the whole-body level as well as within adipose tissue and skeletal muscle in the context of a standardised energy surplus.Trial registration:ISRCTN,ISRCTN18311163. Registered on 24 June 2015. Keywords:Exercise, Overfeeding, Reduced physical activity, Arm crank, Breaking sitting, Moderate-intensity exercise,Metabolism, Adipose tissue, Skeletal muscle and energy imbalance

AB - Background:Short-term overfeeding combined with reduced physical activity impairs metabolic function and alters the expression of key genes within adipose tissue. We have shown that daily vigorous-intensity running can prevent these changes independent of any net effect on energy imbalance. However, which type, intensity and/or duration of exercise best achieves these benefits remains to be ascertained. Methods/design:Forty-eight healthy young men will be recruited and randomly allocated to one of four experimental conditions for 1 week: (1) to ingest 50% more energy than normal by over-consuming their habitual diet whilst simultaneously restricting their physical activity below 4000 steps day−1(i.e. energy surplus; SUR group);(2) the same regimen but with a daily 45-min bout of vigorous-intensity arm crank ergometry at 70% of maximum oxygen uptake (SUR + ARM group); (3) the same regimen but with a daily 45-min bout of moderate-intensity treadmill walking at 50% of maximum oxygen uptake (SUR + MOD group); (4) the same regimen but with the addition of intermittent short bouts of walking during waking hours (SUR + BREAKS group). Critically, all exercise groups will receive additional dietary energy intake to account for the energy expended by exercise,thus maintaining a matched energy surplus. At baseline and follow-up, fasted blood samples, abdominal subcutaneous adipose tissue and skeletal muscle biopsies will be obtained and oral glucose tolerance tests conducted. Discussion:This study will establish the impact of different forms of daily exercise on metabolic function at the whole-body level as well as within adipose tissue and skeletal muscle in the context of a standardised energy surplus.Trial registration:ISRCTN,ISRCTN18311163. Registered on 24 June 2015. Keywords:Exercise, Overfeeding, Reduced physical activity, Arm crank, Breaking sitting, Moderate-intensity exercise,Metabolism, Adipose tissue, Skeletal muscle and energy imbalance

KW - Exercise

KW - Overfeeding

KW - Reduced physical activity

KW - Arm crank

KW - Breaking sitting

KW - Moderate-intensity exercise

KW - Metabolism

KW - Adipose tissue

KW - Skeletal muscle

KW - energy imbalance

U2 - 10.1186/s13063-018-2579-6

DO - 10.1186/s13063-018-2579-6

M3 - Article

VL - 19

JO - Trials

T2 - Trials

JF - Trials

SN - 1745-6215

IS - 1

M1 - 199

ER -