The effect of pressure on halothane binding to hydrated DMPC bilayers

P.-l. Chau, K. M. Tu, K. K. Liang, I. T. Todorov, Stephen J Roser, Robert Barker, Nobuyuki Matubayasi

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Halothane binding to hydrated dimyristoylphosphatidylcholine (DMPC) bilayer membranes has been examined over a wide range of pressures from 105 to 4 × 108 Pa. We show that the solvation of halothane by the membrane and bulk water are both pressure dependent, with an increased pressure driving halothane into the membrane. Analysis of these results shows that this pressure dependence is not the cause of pressure reversal, the process whereby general anaesthetics lose their efficacy at pressures of about 8 × 106 to about 2.5 × 107 Pa.
Original languageEnglish
Pages (from-to)1461-1467
JournalMolecular Physics
Volume110
Issue number13
DOIs
Publication statusPublished - 10 Jul 2012

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