The effect of low volume sprint interval training in patients with non-alcoholic fatty liver disease

Catriona MacLean, John Dillon, John A Babraj, Niels B.J. Vollaard

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives: Exercise is an important part of disease management in patients with non-alcoholic fatty liver disease (NAFLD), but adherence to current exercise recommendations is poor. Novel low-volume sprint interval training (SIT) protocols with total training time commitments of ≤30 min per week have been shown to improve cardiometabolic risk and functional capacity in healthy sedentary participants, but the efficacy of such protocols in the management of NAFLD remains unknown. The aim of the present study was to examine whether a low-volume SIT protocol can be used to improve liver function, insulin resistance, body composition, physical fitness, cognitive function and general well-being in patients with NAFLD. 

Methods: In the present study, 7 men and 2 women with NAFLD (age: 45 ± 8 y, BMI: 28.7 ± 4.1 kg·m−2) completed a 6-week control period followed by 6 weeks of twice-weekly SIT sessions (5–10 × 6-s ‘all-out’ cycle sprints). Body composition, blood pressure, liver function, metabolic function, functional capacity, cognitive function and quality of life were assessed at baseline, following the control period, and following the SIT intervention. 

Results: Walking speed during the walk test (+12%), estimated V̇O2max (+8%), verbal fluency (+44%), and blood platelet count (+12%; all p < 0.05) significantly increased during the control period. These measures remained significantly raised compared to baseline following the SIT intervention, but did not significantly change any further compared to the post-control time-point. Diastolic blood pressure decreased from 87 ± 10 to 77 ± 8 mm Hg from the end of the control period to the end of the SIT intervention (p < 0.05). 

Conclusion: This study does not support the use of 6 weeks of a low volume SIT protocol involving twice-weekly sessions with 5–10 × 6-s ‘all-out’ cycle sprints as an intervention for NAFLD disease management.

Original languageEnglish
Pages (from-to)87-92
Number of pages6
JournalThe Physician and Sportsmedicine
Volume46
Issue number1
Early online date1 Dec 2017
DOIs
Publication statusPublished - 2 Jan 2018

Fingerprint

Disease Management
Blood Pressure
Body Composition
Cognition
Exercise
Physical Fitness
Liver
Non-alcoholic Fatty Liver Disease
High-Intensity Interval Training
Platelet Count
Insulin Resistance
Healthy Volunteers
Quality of Life
Walking Speed
Walk Test
caN protocol

Keywords

  • all-out
  • liver function
  • NAFLD
  • NASH
  • physical function
  • SIT

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

The effect of low volume sprint interval training in patients with non-alcoholic fatty liver disease. / MacLean, Catriona; Dillon, John; Babraj, John A; Vollaard, Niels B.J.

In: The Physician and Sportsmedicine, Vol. 46, No. 1, 02.01.2018, p. 87-92.

Research output: Contribution to journalArticle

MacLean, Catriona ; Dillon, John ; Babraj, John A ; Vollaard, Niels B.J. / The effect of low volume sprint interval training in patients with non-alcoholic fatty liver disease. In: The Physician and Sportsmedicine. 2018 ; Vol. 46, No. 1. pp. 87-92.
@article{cba126babfea491983a6253d41e97d1e,
title = "The effect of low volume sprint interval training in patients with non-alcoholic fatty liver disease",
abstract = "Objectives: Exercise is an important part of disease management in patients with non-alcoholic fatty liver disease (NAFLD), but adherence to current exercise recommendations is poor. Novel low-volume sprint interval training (SIT) protocols with total training time commitments of ≤30 min per week have been shown to improve cardiometabolic risk and functional capacity in healthy sedentary participants, but the efficacy of such protocols in the management of NAFLD remains unknown. The aim of the present study was to examine whether a low-volume SIT protocol can be used to improve liver function, insulin resistance, body composition, physical fitness, cognitive function and general well-being in patients with NAFLD. Methods: In the present study, 7 men and 2 women with NAFLD (age: 45 ± 8 y, BMI: 28.7 ± 4.1 kg·m−2) completed a 6-week control period followed by 6 weeks of twice-weekly SIT sessions (5–10 × 6-s ‘all-out’ cycle sprints). Body composition, blood pressure, liver function, metabolic function, functional capacity, cognitive function and quality of life were assessed at baseline, following the control period, and following the SIT intervention. Results: Walking speed during the walk test (+12{\%}), estimated V̇O2max (+8{\%}), verbal fluency (+44{\%}), and blood platelet count (+12{\%}; all p < 0.05) significantly increased during the control period. These measures remained significantly raised compared to baseline following the SIT intervention, but did not significantly change any further compared to the post-control time-point. Diastolic blood pressure decreased from 87 ± 10 to 77 ± 8 mm Hg from the end of the control period to the end of the SIT intervention (p < 0.05). Conclusion: This study does not support the use of 6 weeks of a low volume SIT protocol involving twice-weekly sessions with 5–10 × 6-s ‘all-out’ cycle sprints as an intervention for NAFLD disease management.",
keywords = "all-out, liver function, NAFLD, NASH, physical function, SIT",
author = "Catriona MacLean and John Dillon and Babraj, {John A} and Vollaard, {Niels B.J.}",
year = "2018",
month = "1",
day = "2",
doi = "10.1080/00913847.2018.1411171",
language = "English",
volume = "46",
pages = "87--92",
journal = "The Physician and Sportsmedicine",
issn = "0091-3847",
publisher = "JTE Multimedia",
number = "1",

}

TY - JOUR

T1 - The effect of low volume sprint interval training in patients with non-alcoholic fatty liver disease

AU - MacLean, Catriona

AU - Dillon, John

AU - Babraj, John A

AU - Vollaard, Niels B.J.

PY - 2018/1/2

Y1 - 2018/1/2

N2 - Objectives: Exercise is an important part of disease management in patients with non-alcoholic fatty liver disease (NAFLD), but adherence to current exercise recommendations is poor. Novel low-volume sprint interval training (SIT) protocols with total training time commitments of ≤30 min per week have been shown to improve cardiometabolic risk and functional capacity in healthy sedentary participants, but the efficacy of such protocols in the management of NAFLD remains unknown. The aim of the present study was to examine whether a low-volume SIT protocol can be used to improve liver function, insulin resistance, body composition, physical fitness, cognitive function and general well-being in patients with NAFLD. Methods: In the present study, 7 men and 2 women with NAFLD (age: 45 ± 8 y, BMI: 28.7 ± 4.1 kg·m−2) completed a 6-week control period followed by 6 weeks of twice-weekly SIT sessions (5–10 × 6-s ‘all-out’ cycle sprints). Body composition, blood pressure, liver function, metabolic function, functional capacity, cognitive function and quality of life were assessed at baseline, following the control period, and following the SIT intervention. Results: Walking speed during the walk test (+12%), estimated V̇O2max (+8%), verbal fluency (+44%), and blood platelet count (+12%; all p < 0.05) significantly increased during the control period. These measures remained significantly raised compared to baseline following the SIT intervention, but did not significantly change any further compared to the post-control time-point. Diastolic blood pressure decreased from 87 ± 10 to 77 ± 8 mm Hg from the end of the control period to the end of the SIT intervention (p < 0.05). Conclusion: This study does not support the use of 6 weeks of a low volume SIT protocol involving twice-weekly sessions with 5–10 × 6-s ‘all-out’ cycle sprints as an intervention for NAFLD disease management.

AB - Objectives: Exercise is an important part of disease management in patients with non-alcoholic fatty liver disease (NAFLD), but adherence to current exercise recommendations is poor. Novel low-volume sprint interval training (SIT) protocols with total training time commitments of ≤30 min per week have been shown to improve cardiometabolic risk and functional capacity in healthy sedentary participants, but the efficacy of such protocols in the management of NAFLD remains unknown. The aim of the present study was to examine whether a low-volume SIT protocol can be used to improve liver function, insulin resistance, body composition, physical fitness, cognitive function and general well-being in patients with NAFLD. Methods: In the present study, 7 men and 2 women with NAFLD (age: 45 ± 8 y, BMI: 28.7 ± 4.1 kg·m−2) completed a 6-week control period followed by 6 weeks of twice-weekly SIT sessions (5–10 × 6-s ‘all-out’ cycle sprints). Body composition, blood pressure, liver function, metabolic function, functional capacity, cognitive function and quality of life were assessed at baseline, following the control period, and following the SIT intervention. Results: Walking speed during the walk test (+12%), estimated V̇O2max (+8%), verbal fluency (+44%), and blood platelet count (+12%; all p < 0.05) significantly increased during the control period. These measures remained significantly raised compared to baseline following the SIT intervention, but did not significantly change any further compared to the post-control time-point. Diastolic blood pressure decreased from 87 ± 10 to 77 ± 8 mm Hg from the end of the control period to the end of the SIT intervention (p < 0.05). Conclusion: This study does not support the use of 6 weeks of a low volume SIT protocol involving twice-weekly sessions with 5–10 × 6-s ‘all-out’ cycle sprints as an intervention for NAFLD disease management.

KW - all-out

KW - liver function

KW - NAFLD

KW - NASH

KW - physical function

KW - SIT

UR - http://www.scopus.com/inward/record.url?scp=85035747277&partnerID=8YFLogxK

U2 - 10.1080/00913847.2018.1411171

DO - 10.1080/00913847.2018.1411171

M3 - Article

VL - 46

SP - 87

EP - 92

JO - The Physician and Sportsmedicine

JF - The Physician and Sportsmedicine

SN - 0091-3847

IS - 1

ER -