The effect of lead time to treatment and of age of onset on developmental outcome at 4 years in infantile spasms: Evidence from the United Kingdom Infantile Spasms Study

F J K O'Callaghan, A L Lux, K Darke, Stuart W Edwards, E Hancock, A L Johnson, C R Kennedy, R W Newton, C M Verity, J P Osborne

Research output: Contribution to journalArticlepeer-review

137 Citations (Scopus)

Abstract

Purpose: Infantile spasms is a severe infantile seizure disorder. Several factors affect developmental outcome, especially the underlying etiology of the spasms. Treatment also affects outcome. Both age at onset of spasms and lead time to treatment (the time from onset of spasms to start of treatment) may be important. We investigated these factors. Methods: Developmental assessment using Vineland Adaptive Behaviour Scales (VABS) at 4 years of age in infants enrolled in the United Kingdom Infantile Spasms Study. Date of or age at onset of spasms was obtained prospectively. Lead time to treatment was then categorized into five categories. The effects of lead time to treatment, age of onset of spasms, etiology, and treatment on developmental outcome were investigated using multiple linear regression. Key Findings: Age of onset ranged (77 infants) from
Original languageEnglish
Pages (from-to)1359-1364
Number of pages6
JournalEpilepsia
Volume52
Issue number7
DOIs
Publication statusPublished - Jul 2011

Keywords

  • age at onset
  • developmental outcome
  • infantile spasms
  • lead time to treatment
  • epileptic spasms

Fingerprint Dive into the research topics of 'The effect of lead time to treatment and of age of onset on developmental outcome at 4 years in infantile spasms: Evidence from the United Kingdom Infantile Spasms Study'. Together they form a unique fingerprint.

Cite this