The effect of calcium co-ingestion on exogenous glucose oxidation during endurance exercise in healthy men: A pilot study

Ben J. Narang; Gareth A. Wallis; Javier T. Gonzalez

doi:10.1080/17461391.2020.1813336

The effect of calcium co-ingestion on exogenous glucose oxidation during endurance exercise in healthy men: A pilot study

Ben J. Narang, Gareth A. Wallis, Javier T. Gonzalez

University of Birmingham

Research output: Contribution to journal › Article › peer-review

2 Citations (SciVal)

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Abstract

The benefits of high exogenous glucose availability for endurance exercise performance are well-established. Exogenous glucose oxidation rates are thought to be limited by intestinal glucose transport. Extracellular calcium in rodent intestine increases the translocation of the intestinal glucose transporter GLUT2 which, if translated to humans, could increase the capacity for exogenous glucose availability during exercise. Therefore, this pilot study aimed to explore the effect of calcium co-ingestion during endurance exercise on exogenous glucose oxidation in healthy men. Eight healthy men cycled for 2 h at 50% peak power output, ingesting either 1.2 g min ⁻¹ dextrose alone (GLU) or with the addition of 2000 mg calcium (GLU + CAL), in a randomised crossover design. Expired breath samples were collected to determine whole-body and exogenous glucose oxidation. Peak exogenous glucose oxidation during GLU was 0.83 ± 0.15 g min ⁻¹, and was not enhanced during GLU + CAL (0.88 ± 0.11 g min ⁻¹, p = 0.541). The relative contributions of exogenous carbohydrate (19 ± 3% vs. 20 ± 2%, p = 0.434), endogenous carbohydrate (65 ± 3% vs. 65 ± 3%, p = 0.822) and fat (16 ± 3% vs. 15 ± 3%, p = 0.677) to total substrate utilisation did not differ between trials. These results suggest the addition of calcium to glucose ingestion, at saturating glucose ingestion rates, does not appear to alter exogenous glucose oxidation during endurance exercise in healthy men.

Original language	English
Pages (from-to)	1156-1164
Number of pages	9
Journal	European Journal of Sport Science
Volume	21
Issue number	8
Early online date	12 Sept 2020
DOIs	https://doi.org/10.1080/17461391.2020.1813336
Publication status	Published - 31 Dec 2021

Bibliographical note

Funding Information:
This work was supported by a Nutrition Society Summer Studentship award. J.T.G. has received research funding and/or has acted as a consultant for Arla Foods Ingredients, Lucozade Ribena Suntory, Kenniscentrum Suiker and Voeding, and PepsiCo. G.A.W has received research funding and/or has acted as a consultant for GlaxoSmithKline Ltd, Sugar Nutrition UK, Lucozade Ribena Suntory Ltd, Dairy Management Inc. and Volac International Ltd. Author Contributions: B.J.N., G. A. W. and J. T. G.: conception and design, data analysis and interpretation. B.J.N. and J.T.G.: manuscript writing. B.J.N.: data collection. All authors read and approved the final manuscript.

Funding Information:
This work was supported by The Nutrition Society UK [grant number N/A]. This work was supported by a Nutrition Society Summer Studentship award. J.T.G. has received research funding and/or has acted as a consultant for Arla Foods Ingredients, Lucozade Ribena Suntory, Kenniscentrum Suiker and Voeding, and PepsiCo. G.A.W has received research funding and/or has acted as a consultant for GlaxoSmithKline Ltd, Sugar Nutrition UK, Lucozade Ribena Suntory Ltd, Dairy Management Inc. and Volac International Ltd. Author Contributions: B.J.N., G. A. W. and J. T. G.: conception and design, data analysis and interpretation. B.J.N. and J.T.G.: manuscript writing. B.J.N.: data collection. All authors read and approved the final manuscript.

Publisher Copyright:
© 2020 European College of Sport Science.

Keywords

Calcium
carbohydrate
endurance exercise
exogenous glucose oxidation
intestinal absorption
metabolism
sports nutrition

ASJC Scopus subject areas

Orthopedics and Sports Medicine
Physical Therapy, Sports Therapy and Rehabilitation

Access to Document

10.1080/17461391.2020.1813336

Calcium_Manuscript_Final_CLEAN
This is an Accepted Manuscript of an article published by Taylor & Francis in European Journal of Sport Science on 12/09/2020, available online: https://www.tandfonline.com/doi/full/10.1080/17461391.2020.1813336
Accepted author manuscript, 418 KB

Cite this

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title = "The effect of calcium co-ingestion on exogenous glucose oxidation during endurance exercise in healthy men: A pilot study",

abstract = "The benefits of high exogenous glucose availability for endurance exercise performance are well-established. Exogenous glucose oxidation rates are thought to be limited by intestinal glucose transport. Extracellular calcium in rodent intestine increases the translocation of the intestinal glucose transporter GLUT2 which, if translated to humans, could increase the capacity for exogenous glucose availability during exercise. Therefore, this pilot study aimed to explore the effect of calcium co-ingestion during endurance exercise on exogenous glucose oxidation in healthy men. Eight healthy men cycled for 2 h at 50% peak power output, ingesting either 1.2 g min −1 dextrose alone (GLU) or with the addition of 2000 mg calcium (GLU + CAL), in a randomised crossover design. Expired breath samples were collected to determine whole-body and exogenous glucose oxidation. Peak exogenous glucose oxidation during GLU was 0.83 ± 0.15 g min −1, and was not enhanced during GLU + CAL (0.88 ± 0.11 g min −1, p = 0.541). The relative contributions of exogenous carbohydrate (19 ± 3% vs. 20 ± 2%, p = 0.434), endogenous carbohydrate (65 ± 3% vs. 65 ± 3%, p = 0.822) and fat (16 ± 3% vs. 15 ± 3%, p = 0.677) to total substrate utilisation did not differ between trials. These results suggest the addition of calcium to glucose ingestion, at saturating glucose ingestion rates, does not appear to alter exogenous glucose oxidation during endurance exercise in healthy men. ",

keywords = "Calcium, carbohydrate, endurance exercise, exogenous glucose oxidation, intestinal absorption, metabolism, sports nutrition",

author = "Narang, {Ben J.} and Wallis, {Gareth A.} and Gonzalez, {Javier T.}",

note = "Funding Information: This work was supported by a Nutrition Society Summer Studentship award. J.T.G. has received research funding and/or has acted as a consultant for Arla Foods Ingredients, Lucozade Ribena Suntory, Kenniscentrum Suiker and Voeding, and PepsiCo. G.A.W has received research funding and/or has acted as a consultant for GlaxoSmithKline Ltd, Sugar Nutrition UK, Lucozade Ribena Suntory Ltd, Dairy Management Inc. and Volac International Ltd. Author Contributions: B.J.N., G. A. W. and J. T. G.: conception and design, data analysis and interpretation. B.J.N. and J.T.G.: manuscript writing. B.J.N.: data collection. All authors read and approved the final manuscript. Funding Information: This work was supported by The Nutrition Society UK [grant number N/A]. This work was supported by a Nutrition Society Summer Studentship award. J.T.G. has received research funding and/or has acted as a consultant for Arla Foods Ingredients, Lucozade Ribena Suntory, Kenniscentrum Suiker and Voeding, and PepsiCo. G.A.W has received research funding and/or has acted as a consultant for GlaxoSmithKline Ltd, Sugar Nutrition UK, Lucozade Ribena Suntory Ltd, Dairy Management Inc. and Volac International Ltd. Author Contributions: B.J.N., G. A. W. and J. T. G.: conception and design, data analysis and interpretation. B.J.N. and J.T.G.: manuscript writing. B.J.N.: data collection. All authors read and approved the final manuscript. Publisher Copyright: {\textcopyright} 2020 European College of Sport Science.",

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N1 - Funding Information: This work was supported by a Nutrition Society Summer Studentship award. J.T.G. has received research funding and/or has acted as a consultant for Arla Foods Ingredients, Lucozade Ribena Suntory, Kenniscentrum Suiker and Voeding, and PepsiCo. G.A.W has received research funding and/or has acted as a consultant for GlaxoSmithKline Ltd, Sugar Nutrition UK, Lucozade Ribena Suntory Ltd, Dairy Management Inc. and Volac International Ltd. Author Contributions: B.J.N., G. A. W. and J. T. G.: conception and design, data analysis and interpretation. B.J.N. and J.T.G.: manuscript writing. B.J.N.: data collection. All authors read and approved the final manuscript. Funding Information: This work was supported by The Nutrition Society UK [grant number N/A]. This work was supported by a Nutrition Society Summer Studentship award. J.T.G. has received research funding and/or has acted as a consultant for Arla Foods Ingredients, Lucozade Ribena Suntory, Kenniscentrum Suiker and Voeding, and PepsiCo. G.A.W has received research funding and/or has acted as a consultant for GlaxoSmithKline Ltd, Sugar Nutrition UK, Lucozade Ribena Suntory Ltd, Dairy Management Inc. and Volac International Ltd. Author Contributions: B.J.N., G. A. W. and J. T. G.: conception and design, data analysis and interpretation. B.J.N. and J.T.G.: manuscript writing. B.J.N.: data collection. All authors read and approved the final manuscript. Publisher Copyright: © 2020 European College of Sport Science.

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N2 - The benefits of high exogenous glucose availability for endurance exercise performance are well-established. Exogenous glucose oxidation rates are thought to be limited by intestinal glucose transport. Extracellular calcium in rodent intestine increases the translocation of the intestinal glucose transporter GLUT2 which, if translated to humans, could increase the capacity for exogenous glucose availability during exercise. Therefore, this pilot study aimed to explore the effect of calcium co-ingestion during endurance exercise on exogenous glucose oxidation in healthy men. Eight healthy men cycled for 2 h at 50% peak power output, ingesting either 1.2 g min −1 dextrose alone (GLU) or with the addition of 2000 mg calcium (GLU + CAL), in a randomised crossover design. Expired breath samples were collected to determine whole-body and exogenous glucose oxidation. Peak exogenous glucose oxidation during GLU was 0.83 ± 0.15 g min −1, and was not enhanced during GLU + CAL (0.88 ± 0.11 g min −1, p = 0.541). The relative contributions of exogenous carbohydrate (19 ± 3% vs. 20 ± 2%, p = 0.434), endogenous carbohydrate (65 ± 3% vs. 65 ± 3%, p = 0.822) and fat (16 ± 3% vs. 15 ± 3%, p = 0.677) to total substrate utilisation did not differ between trials. These results suggest the addition of calcium to glucose ingestion, at saturating glucose ingestion rates, does not appear to alter exogenous glucose oxidation during endurance exercise in healthy men.

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The effect of calcium co-ingestion on exogenous glucose oxidation during endurance exercise in healthy men: A pilot study

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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