Abstract
The combination of three reagents-a tridentate pybox ligand (pybox = pyridine bis(oxazoline)), magnesium perchlorate, and Hunig base (iPr 2EtN)-allows the catalytic generation of a chiral glycine enolate from 1 that undergoes highly enantioselective addition to a range of aryl aldehydes 2. The protected aryl β-hydroxy-α-amino acid products obtained include a protected version of one of the aryl serine units present in the glycopeptide antibiotic vancomycin.
Original language | English |
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Pages (from-to) | 1543-1545 |
Number of pages | 3 |
Journal | Angewandte Chemie International Edition |
Volume | 44 |
Issue number | 10 |
DOIs | |
Publication status | Published - 2005 |
Keywords
- Synthesis (chemical)
- Magnesium printing plates
- Amino acids
- Antibiotics
- Aldehydes
- Catalyst activity