The combination of three reagents-a tridentate pybox ligand (pybox = pyridine bis(oxazoline)), magnesium perchlorate, and Hunig base (iPr 2EtN)-allows the catalytic generation of a chiral glycine enolate from 1 that undergoes highly enantioselective addition to a range of aryl aldehydes 2. The protected aryl β-hydroxy-α-amino acid products obtained include a protected version of one of the aryl serine units present in the glycopeptide antibiotic vancomycin.
|Number of pages||3|
|Journal||Angewandte Chemie-International Edition|
|Publication status||Published - 2005|
- Synthesis (chemical)
- Magnesium printing plates
- Amino acids
- Catalyst activity