The determination of a diffusional pathlength through the stratum corneum

Annette L. Bunge; Richard H. Guy; Jonathan Hadgraft

doi:10.1016/S0378-5173(99)00161-1

The determination of a diffusional pathlength through the stratum corneum

Annette L. Bunge, Richard H. Guy, Jonathan Hadgraft

Research output: Contribution to journal › Article › peer-review

19 Citations (SciVal)

Abstract

The stratum corneum possesses a very heterogenous structure. As such a diffusing molecule can access a number of different pathways. It is probable that the excellent barrier properties of the stratum corneum result from a tortuous diffusional pathway around the dead cells. However, there are considerable problems in designing diffusion experiments and analysing the data to prove, without doubt, which is the predominant pathway. The mathematical problems posed are discussed in this article. Copyright (C) 1999 Elsevier Science B.V.

Original language	English
Pages (from-to)	121-124
Number of pages	4
Journal	International Journal of Pharmaceutics
Volume	188
Issue number	1
DOIs	https://doi.org/10.1016/S0378-5173(99)00161-1
Publication status	Published - 15 Oct 1999

Bibliographical note

Funding Information:
The authors acknowledge support from the US Environmental Protection Agency, the US Air Force Office of Scientific Research, and the National Institute of Environmental Health Sciences.

Keywords

Diffusional pathlength
Human stratum corneum

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/S0378-5173(99)00161-1

Cite this

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AU - Guy, Richard H.

AU - Hadgraft, Jonathan

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N2 - The stratum corneum possesses a very heterogenous structure. As such a diffusing molecule can access a number of different pathways. It is probable that the excellent barrier properties of the stratum corneum result from a tortuous diffusional pathway around the dead cells. However, there are considerable problems in designing diffusion experiments and analysing the data to prove, without doubt, which is the predominant pathway. The mathematical problems posed are discussed in this article. Copyright (C) 1999 Elsevier Science B.V.

AB - The stratum corneum possesses a very heterogenous structure. As such a diffusing molecule can access a number of different pathways. It is probable that the excellent barrier properties of the stratum corneum result from a tortuous diffusional pathway around the dead cells. However, there are considerable problems in designing diffusion experiments and analysing the data to prove, without doubt, which is the predominant pathway. The mathematical problems posed are discussed in this article. Copyright (C) 1999 Elsevier Science B.V.

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IS - 1

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The determination of a diffusional pathlength through the stratum corneum

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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