The determination of a diffusional pathlength through the stratum corneum

Annette L. Bunge, Richard H. Guy, Jonathan Hadgraft

Research output: Contribution to journalArticlepeer-review

19 Citations (SciVal)


The stratum corneum possesses a very heterogenous structure. As such a diffusing molecule can access a number of different pathways. It is probable that the excellent barrier properties of the stratum corneum result from a tortuous diffusional pathway around the dead cells. However, there are considerable problems in designing diffusion experiments and analysing the data to prove, without doubt, which is the predominant pathway. The mathematical problems posed are discussed in this article. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)121-124
Number of pages4
JournalInternational Journal of Pharmaceutics
Issue number1
Publication statusPublished - 15 Oct 1999


  • Diffusional pathlength
  • Human stratum corneum

ASJC Scopus subject areas

  • Pharmaceutical Science


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