TY - JOUR
T1 - The determination of a diffusional pathlength through the stratum corneum
AU - Bunge, Annette L.
AU - Guy, Richard H.
AU - Hadgraft, Jonathan
N1 - Funding Information:
The authors acknowledge support from the US Environmental Protection Agency, the US Air Force Office of Scientific Research, and the National Institute of Environmental Health Sciences.
PY - 1999/10/15
Y1 - 1999/10/15
N2 - The stratum corneum possesses a very heterogenous structure. As such a diffusing molecule can access a number of different pathways. It is probable that the excellent barrier properties of the stratum corneum result from a tortuous diffusional pathway around the dead cells. However, there are considerable problems in designing diffusion experiments and analysing the data to prove, without doubt, which is the predominant pathway. The mathematical problems posed are discussed in this article. Copyright (C) 1999 Elsevier Science B.V.
AB - The stratum corneum possesses a very heterogenous structure. As such a diffusing molecule can access a number of different pathways. It is probable that the excellent barrier properties of the stratum corneum result from a tortuous diffusional pathway around the dead cells. However, there are considerable problems in designing diffusion experiments and analysing the data to prove, without doubt, which is the predominant pathway. The mathematical problems posed are discussed in this article. Copyright (C) 1999 Elsevier Science B.V.
KW - Diffusional pathlength
KW - Human stratum corneum
UR - http://www.scopus.com/inward/record.url?scp=0032822832&partnerID=8YFLogxK
U2 - 10.1016/S0378-5173(99)00161-1
DO - 10.1016/S0378-5173(99)00161-1
M3 - Article
C2 - 10528090
AN - SCOPUS:0032822832
VL - 188
SP - 121
EP - 124
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
SN - 0378-5173
IS - 1
ER -