Abstract
Invasive aspergillosis has emerged as one of the most common life-threatening fungal disease of humans. The emergence of antifungal resistant pathogens represents a current and increasing threat to society. In turn, new strategies to combat fungal infection are urgently required. Fungal adaptations to stresses experienced within the human host are a prerequisite for the survival and virulence strategies of the pathogen. Here, we review the latest information on the signalling pathways in Aspergillus fumigatus that contribute to stress adaptations and virulence, while highlighting their potential as targets for the development of novel combinational antifungal therapies.
| Original language | English |
|---|---|
| Pages (from-to) | 243-253 |
| Number of pages | 11 |
| Journal | Journal of Microbiology |
| Volume | 54 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1 Mar 2016 |
Funding
We would like to thank the Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq) and the Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo (FAPESP) Brazil, plus the UK Biotechnology and Biological Sciences Research Council (BBSRC) [BB/J/004383/1] for providing financial support. Rothamsted Research receives grant-aided support from the Biotechnology and Biological Sciences Research Council (BBSRC) UK as part of the 20:20? wheat programme.
Keywords
- aspergillosis
- cell wall stress
- fungicide resistance
- heat shock
- hypoxia
- osmotic stress
- oxidative stress
ASJC Scopus subject areas
- Microbiology
- Applied Microbiology and Biotechnology
