The contribution of Aspergillus fumigatus stress responses to virulence and antifungal resistance

Neil A. Brown, Gustavo H. Goldman

Research output: Contribution to journalReview article

33 Citations (Scopus)

Abstract

Invasive aspergillosis has emerged as one of the most common life-threatening fungal disease of humans. The emergence of antifungal resistant pathogens represents a current and increasing threat to society. In turn, new strategies to combat fungal infection are urgently required. Fungal adaptations to stresses experienced within the human host are a prerequisite for the survival and virulence strategies of the pathogen. Here, we review the latest information on the signalling pathways in Aspergillus fumigatus that contribute to stress adaptations and virulence, while highlighting their potential as targets for the development of novel combinational antifungal therapies.

Original languageEnglish
Pages (from-to)243-253
Number of pages11
JournalJournal of Microbiology
Volume54
Issue number3
DOIs
Publication statusPublished - 1 Mar 2016

Keywords

  • aspergillosis
  • cell wall stress
  • fungicide resistance
  • heat shock
  • hypoxia
  • osmotic stress
  • oxidative stress

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology

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