The clinical aspects of autoantibodies

John D. Paulin, Neil McHugh

Research output: Chapter or section in a book/report/conference proceedingChapter or section

2 Citations (SciVal)


Disease classification in systemic sclerosis (SSc) is based primarily on the extent of skin involvement due to the recognition of its capacity to predict organ-specific manifestations. However, as shall be discussed in this chapter, antibody specificity, despite certain limitations, may prove of greater importance in predicting disease course and prognosis [1]. Circulating autoantibodies are attractive as biomarkers in SSc owing to their high specificity, the mutual exclusivity of the major SScautoantibody subtypes, their persistence for the duration of illness and most importantly, the characteristic constellation of clinical features associated with individual autoantibody groups [2, 3]. It is important to note, however, that the major clinical associations with SSc specific autoantibody reactivities, whilst of major prognostic value, are not absolute and organspecific manifestations can occur in the presence of any autoantibody reactivity [4].

Original languageEnglish
Title of host publicationScleroderma
Subtitle of host publicationFrom Pathogenesis to Comprehensive Management
EditorsJohn Varga, Christopher P. Denton, Fredrick M. Wigley
Place of PublicationNew York
Number of pages17
ISBN (Electronic)9781441957740
ISBN (Print)9781441957733
Publication statusPublished - 1 Jan 2012


  • ANA
  • Anticentromere
  • Autoantibody types
  • Clinical aspects of autoantibodies
  • Methods of autoantibody detection
  • RNA polymerase III
  • Scl-70

ASJC Scopus subject areas

  • General Medicine


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