The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury

Katerina Vafeiadou, David Vauzour, Hung Yi Lee, Ana Rodriguez-Mateos, Robert J Williams, Jeremy P E Spencer

Research output: Contribution to journalArticle

145 Citations (Scopus)

Abstract

Neuroinflammation plays an integral role in the progression of neurodegeneration. In this study we investigated the anti-inflammatory effects of different classes of flavonoids (flavanones, flavanols and anthocyanidins) in primary mixed glial cells. We found that the flavanones naringenin and hesperetin and the flavanols (+)-catechin and (-)-epicatechin, but not the anthocyanidins cyanidin and pelargonidin, attenuated LPS/IFN-gamma-induced TNF-alpha production in glial cells. Naringenin also inhibited LPS/IFN-gamma-induced iNOS expression and nitric oxide production in glial cells, thus showing the strongest anti-inflammatory activity among all flavonoids tested. Moreover, naringenin protected against inflammatory-induced neuronal death in a primary neuronal-glial co-culture system. Naringenin also inhibited LPS/IFN-gamma-induced p38 mitogen-activated protein kinase (MAPK) phosphorylation and downstream signal transducer and activator of transcription-1 (STAT-1) in LPS/IFN-gamma stimulated primary mixed glial cells. Taken together, our results suggest that naringenin may produce an anti-inflammatory effect in LPS/IFN-gamma stimulated glial cells that may be due to its interaction with p38 signalling cascades and the STAT-1 transcription factor.
Original languageEnglish
Pages (from-to)100-109
Number of pages10
JournalArchives of Biochemistry and Biophysics
Volume484
Issue number1
DOIs
Publication statusPublished - 1 Apr 2009

Fingerprint Dive into the research topics of 'The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury'. Together they form a unique fingerprint.

  • Cite this