The Chameleon of Retaining Glycoside Hydrolases and Retaining Glycosyl Transferases: The Catalytic Nucleophile

R. V. Stick, A. G. Watts

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

This paper addresses the existence and role of a catalytic nucleophile in retaining glycoside hydrolases and retaining glycosyl transferases. Although the former has now been established beyond doubt, such is not the case with the latter. We report reliable procedures for the synthesis of various 2-deoxy-2-fluoro glycosyl nucleoside diphosphates, useful donor analogues for the study of the mechanism of action of retaining glycosyl transferases.
Original languageEnglish
Pages (from-to)541-554
Number of pages15
JournalMonatshefte fur Chemie
Volume133
Issue number4 SPI
DOIs
Publication statusPublished - 1 Apr 2002

ASJC Scopus subject areas

  • Chemistry(all)

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