The chameleon of retaining glycoside hydrolases and retaining glycosyl transferases:: The catalytic nucleophile

Robert V. Stick; Andrew G. Watts

doi:10.1007/s007060200027

The chameleon of retaining glycoside hydrolases and retaining glycosyl transferases: The catalytic nucleophile

Robert V. Stick
, Andrew G. Watts

The University of Western Australia

Research output: Contribution to journal › Article › peer-review

13 Citations (SciVal)

Abstract

This paper addresses the existence and role of a catalytic nucleophile in retaining glycoside hydrolases and retaining glycosyl transferases. Although the former has now been established beyond doubt, such is not the case with the latter. We report reliable procedures for the synthesis of various 2-deoxy-2-fluoro glycosyl nucleoside diphosphates, useful donor analogues for the study of the mechanism of action of retaining glycosyl transferases.

Original language	English
Pages (from-to)	541-554
Number of pages	14
Journal	Monatshefte fur Chemie
Volume	133
Issue number	4
DOIs	https://doi.org/10.1007/s007060200027
Publication status	Published - 27 Apr 2002

Keywords

2-Deoxy-2-fluoro hexopyranoses
Glycoside hydrolases
Glycosyl transferases

ASJC Scopus subject areas

General Chemistry

Access to Document

10.1007/s007060200027

Cite this

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title = "The chameleon of retaining glycoside hydrolases and retaining glycosyl transferases:: The catalytic nucleophile",

abstract = "This paper addresses the existence and role of a catalytic nucleophile in retaining glycoside hydrolases and retaining glycosyl transferases. Although the former has now been established beyond doubt, such is not the case with the latter. We report reliable procedures for the synthesis of various 2-deoxy-2-fluoro glycosyl nucleoside diphosphates, useful donor analogues for the study of the mechanism of action of retaining glycosyl transferases.",

keywords = "2-Deoxy-2-fluoro hexopyranoses, Glycoside hydrolases, Glycosyl transferases",

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N2 - This paper addresses the existence and role of a catalytic nucleophile in retaining glycoside hydrolases and retaining glycosyl transferases. Although the former has now been established beyond doubt, such is not the case with the latter. We report reliable procedures for the synthesis of various 2-deoxy-2-fluoro glycosyl nucleoside diphosphates, useful donor analogues for the study of the mechanism of action of retaining glycosyl transferases.

AB - This paper addresses the existence and role of a catalytic nucleophile in retaining glycoside hydrolases and retaining glycosyl transferases. Although the former has now been established beyond doubt, such is not the case with the latter. We report reliable procedures for the synthesis of various 2-deoxy-2-fluoro glycosyl nucleoside diphosphates, useful donor analogues for the study of the mechanism of action of retaining glycosyl transferases.

KW - 2-Deoxy-2-fluoro hexopyranoses

KW - Glycoside hydrolases

KW - Glycosyl transferases

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DO - 10.1007/s007060200027

M3 - Article

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