The CCN family of proteins: structure-function relationships

Kenneth P Holbourn, K Ravi Acharya, B Perbal

Research output: Contribution to journalArticle

273 Citations (Scopus)

Abstract

The CCN proteins are key signalling and regulatory molecules involved in many vital biological functions, including cell proliferation, angiogenesis, tumourigenesis and wound healing. How these proteins influence such a range of functions remains incompletely understood but is probably related to their discrete modular nature and a complex array of intra- and inter-molecular interactions with a variety of regulatory proteins and ligands. Although certain aspects of their biology can be attributed to the four individual modules that constitute the CCN proteins, recent results suggest that some of their biological functions require cooperation between modules. Indeed, the modular structure of CCN proteins provides important insight into their structure-function relationships.
Original languageEnglish
Pages (from-to)461-473
Number of pages13
JournalTrends in Biochemical Sciences
Volume33
Issue number10
DOIs
Publication statusPublished - Oct 2008

Keywords

  • extracellular-matrix
  • crystal-structure
  • tissue growth-factor
  • factor-binding-proteins
  • vascular endothelial-cells
  • fibroblasts
  • vonwillebrand-factor
  • heparin-binding
  • igfbp superfamily
  • mouse embryonic
  • bone morphogenetic proteins

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