The catalytic ortho-arylation of tyrosine

Robin B. Bedford; Mairi F. Haddow; Ruth L. Webster; Charlotte J. Mitchell

doi:10.1039/b906119c

The catalytic ortho-arylation of tyrosine

Robin B. Bedford, Mairi F. Haddow, Ruth L. Webster, Charlotte J. Mitchell

Department of Chemistry

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46 Citations (SciVal)

Abstract

The rhodium-catalysed direct ortho-arylation of protected racemic 2-tert-butyl tyrosine has been developed. The subsequent removal of the tert-butyl group yields the 2-arylated tyrosine which can undergo further rhodium-based arylation at the 6-position. In one instance a product formed by further arylation of the diarylated species was isolated.

Original language	English
Pages (from-to)	3119-3127
Journal	Organic and Biomolecular Chemistry
Volume	7
Issue number	15
Early online date	14 Jun 2009
DOIs	https://doi.org/10.1039/b906119c
Publication status	Published - 2009

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title = "The catalytic ortho-arylation of tyrosine",

abstract = "The rhodium-catalysed direct ortho-arylation of protected racemic 2-tert-butyl tyrosine has been developed. The subsequent removal of the tert-butyl group yields the 2-arylated tyrosine which can undergo further rhodium-based arylation at the 6-position. In one instance a product formed by further arylation of the diarylated species was isolated.",

author = "Bedford, \{Robin B.\} and Haddow, \{Mairi F.\} and Webster, \{Ruth L.\} and Mitchell, \{Charlotte J.\}",

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AU - Bedford, Robin B.

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AU - Webster, Ruth L.

AU - Mitchell, Charlotte J.

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N2 - The rhodium-catalysed direct ortho-arylation of protected racemic 2-tert-butyl tyrosine has been developed. The subsequent removal of the tert-butyl group yields the 2-arylated tyrosine which can undergo further rhodium-based arylation at the 6-position. In one instance a product formed by further arylation of the diarylated species was isolated.

AB - The rhodium-catalysed direct ortho-arylation of protected racemic 2-tert-butyl tyrosine has been developed. The subsequent removal of the tert-butyl group yields the 2-arylated tyrosine which can undergo further rhodium-based arylation at the 6-position. In one instance a product formed by further arylation of the diarylated species was isolated.

UR - https://www.scopus.com/pages/publications/68949100399

UR - http://dx.doi.org/10.1039/b906119c

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DO - 10.1039/b906119c

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SN - 1477-0520

VL - 7

SP - 3119

EP - 3127

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 15

ER -

The catalytic ortho-arylation of tyrosine

Abstract

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