The catalytic ortho-arylation of tyrosine

Robin B. Bedford, Mairi F. Haddow, Ruth L. Webster, Charlotte J. Mitchell

Research output: Contribution to journalArticlepeer-review

40 Citations (SciVal)


The rhodium-catalysed direct ortho-arylation of protected racemic 2-tert-butyl tyrosine has been developed. The subsequent removal of the tert-butyl group yields the 2-arylated tyrosine which can undergo further rhodium-based arylation at the 6-position. In one instance a product formed by further arylation of the diarylated species was isolated.
Original languageEnglish
Pages (from-to)3119-3127
JournalOrganic and Biomolecular Chemistry
Issue number15
Early online date14 Jun 2009
Publication statusPublished - 2009


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