The assessment of ankylosing spondylitis in clinical practice

Raj Sengupta, Millicent A Stone

Research output: Contribution to journalReview article

36 Citations (Scopus)

Abstract

Ankylosing Spondylitis (AS) is a chronic inflammatory arthritis that predominantly affects the axial skeleton in adolescent patients causing spinal pain and stiffness. There is a marked delay, on average 8 years, between onset of disease symptoms and clinical diagnosis. The distinction between the symptoms of mechanical and inflammatory back pain remains one of the main contributing factors for the delay in diagnosis. Several classification criteria exist to aid the diagnosis of AS, but their accuracy is poor. The Ankylosing Spondylitis Assessment Study group (ASAS) has defined a core set of domains for clinical outcome measurement in AS in order to assess the disease process in individual patients and to identify those with rapidly progressive disease. New therapies, such as the tumor necrosis factor (TNF) inhibitors, have transformed the treatment paradigm in AS, especially for those patients with aggressive disease. Thus, the definition of both patient selection criteria for these agents and the development of clinical methods to assess response to therapy have become a priority. This Review focuses on measuring the degree of disease activity, function and damage in patients with AS in an ambulatory care setting, and the assessment of suitability of various outcome measures for monitoring response to treatment with TNF inhibitors.

Original languageEnglish
Pages (from-to)496-503
Number of pages8
JournalNature Clinical Practice Rheumatology
Volume3
Issue number9
DOIs
Publication statusPublished - Sep 2007

Fingerprint

Ankylosing Spondylitis
Patient Selection
Tumor Necrosis Factor-alpha
Therapeutics
Back Pain
Ambulatory Care
Skeleton
Arthritis
Outcome Assessment (Health Care)
Pain

Keywords

  • Activities of Daily Living
  • Ambulatory Care
  • Back Pain
  • Biomarkers
  • Humans
  • Immunologic Factors
  • Joints
  • Mobility Limitation
  • Sickness Impact Profile
  • Spine
  • Spondylitis, Ankylosing
  • Tumor Necrosis Factor-alpha
  • Journal Article
  • Review

Cite this

The assessment of ankylosing spondylitis in clinical practice. / Sengupta, Raj; Stone, Millicent A.

In: Nature Clinical Practice Rheumatology, Vol. 3, No. 9, 09.2007, p. 496-503.

Research output: Contribution to journalReview article

@article{b1249ee182a2425ba07d1fe0e49eac57,
title = "The assessment of ankylosing spondylitis in clinical practice",
abstract = "Ankylosing Spondylitis (AS) is a chronic inflammatory arthritis that predominantly affects the axial skeleton in adolescent patients causing spinal pain and stiffness. There is a marked delay, on average 8 years, between onset of disease symptoms and clinical diagnosis. The distinction between the symptoms of mechanical and inflammatory back pain remains one of the main contributing factors for the delay in diagnosis. Several classification criteria exist to aid the diagnosis of AS, but their accuracy is poor. The Ankylosing Spondylitis Assessment Study group (ASAS) has defined a core set of domains for clinical outcome measurement in AS in order to assess the disease process in individual patients and to identify those with rapidly progressive disease. New therapies, such as the tumor necrosis factor (TNF) inhibitors, have transformed the treatment paradigm in AS, especially for those patients with aggressive disease. Thus, the definition of both patient selection criteria for these agents and the development of clinical methods to assess response to therapy have become a priority. This Review focuses on measuring the degree of disease activity, function and damage in patients with AS in an ambulatory care setting, and the assessment of suitability of various outcome measures for monitoring response to treatment with TNF inhibitors.",
keywords = "Activities of Daily Living, Ambulatory Care, Back Pain, Biomarkers, Humans, Immunologic Factors, Joints, Mobility Limitation, Sickness Impact Profile, Spine, Spondylitis, Ankylosing, Tumor Necrosis Factor-alpha, Journal Article, Review",
author = "Raj Sengupta and Stone, {Millicent A}",
note = "ID number: ISI:000249138000007",
year = "2007",
month = "9",
doi = "10.1038/ncprheum0591",
language = "English",
volume = "3",
pages = "496--503",
journal = "Nature Clinical Practice Rheumatology",
issn = "1745-8382",
publisher = "Nature Publishing Group",
number = "9",

}

TY - JOUR

T1 - The assessment of ankylosing spondylitis in clinical practice

AU - Sengupta, Raj

AU - Stone, Millicent A

N1 - ID number: ISI:000249138000007

PY - 2007/9

Y1 - 2007/9

N2 - Ankylosing Spondylitis (AS) is a chronic inflammatory arthritis that predominantly affects the axial skeleton in adolescent patients causing spinal pain and stiffness. There is a marked delay, on average 8 years, between onset of disease symptoms and clinical diagnosis. The distinction between the symptoms of mechanical and inflammatory back pain remains one of the main contributing factors for the delay in diagnosis. Several classification criteria exist to aid the diagnosis of AS, but their accuracy is poor. The Ankylosing Spondylitis Assessment Study group (ASAS) has defined a core set of domains for clinical outcome measurement in AS in order to assess the disease process in individual patients and to identify those with rapidly progressive disease. New therapies, such as the tumor necrosis factor (TNF) inhibitors, have transformed the treatment paradigm in AS, especially for those patients with aggressive disease. Thus, the definition of both patient selection criteria for these agents and the development of clinical methods to assess response to therapy have become a priority. This Review focuses on measuring the degree of disease activity, function and damage in patients with AS in an ambulatory care setting, and the assessment of suitability of various outcome measures for monitoring response to treatment with TNF inhibitors.

AB - Ankylosing Spondylitis (AS) is a chronic inflammatory arthritis that predominantly affects the axial skeleton in adolescent patients causing spinal pain and stiffness. There is a marked delay, on average 8 years, between onset of disease symptoms and clinical diagnosis. The distinction between the symptoms of mechanical and inflammatory back pain remains one of the main contributing factors for the delay in diagnosis. Several classification criteria exist to aid the diagnosis of AS, but their accuracy is poor. The Ankylosing Spondylitis Assessment Study group (ASAS) has defined a core set of domains for clinical outcome measurement in AS in order to assess the disease process in individual patients and to identify those with rapidly progressive disease. New therapies, such as the tumor necrosis factor (TNF) inhibitors, have transformed the treatment paradigm in AS, especially for those patients with aggressive disease. Thus, the definition of both patient selection criteria for these agents and the development of clinical methods to assess response to therapy have become a priority. This Review focuses on measuring the degree of disease activity, function and damage in patients with AS in an ambulatory care setting, and the assessment of suitability of various outcome measures for monitoring response to treatment with TNF inhibitors.

KW - Activities of Daily Living

KW - Ambulatory Care

KW - Back Pain

KW - Biomarkers

KW - Humans

KW - Immunologic Factors

KW - Joints

KW - Mobility Limitation

KW - Sickness Impact Profile

KW - Spine

KW - Spondylitis, Ankylosing

KW - Tumor Necrosis Factor-alpha

KW - Journal Article

KW - Review

U2 - 10.1038/ncprheum0591

DO - 10.1038/ncprheum0591

M3 - Review article

VL - 3

SP - 496

EP - 503

JO - Nature Clinical Practice Rheumatology

JF - Nature Clinical Practice Rheumatology

SN - 1745-8382

IS - 9

ER -