The AMPA receptor antagonist perampanel suppresses epileptic activity in human focal cortical dysplasia

Anderson Brito da Silva, Jane Pennifold, Ben Henley, Koustav Chatterjee, David Bateman, Roger W. Whittaker, Abhijit Joshi, Hrishikesh Kumar, Claire Nicholson, Mark R. Baker, Stuart D. Greenhill, Richard Walsh, Stefano Seri, Roland S.G. Jones, Gavin L. Woodhall, Mark O Cunningham

Research output: Contribution to journalArticlepeer-review

Abstract

Focal cortical dysplasia (FCD) is one of the most common malformations causing refractory epilepsy. Dysregulation of glutamatergic systems plays a critical role in the hyperexcitability of dysplastic neurons in FCD lesions. The pharmacoresistant nature of epilepsy associated with FCD may be due to a lack of well-tolerated and precise antiepileptic drugs that can target glutamate receptors. Here, for the first time in human FCD brain slices, we show that the established, noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist, perampanel has potent antiepileptic action. Moreover, we demonstrate that this effect is due to a reduction in burst firing behavior in human FCD microcircuits. These data support a potential role for the treatment of refractory epilepsy associated with FCD in human patients.

Original languageEnglish
Pages (from-to)488-495
Number of pages8
JournalEpilepsia Open
Volume7
Issue number3
Early online date11 May 2022
DOIs
Publication statusPublished - 30 Sep 2022

Keywords

  • AMPA
  • epilepsy
  • focal cortical dysplasia
  • glutamate
  • perampanel

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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