Textile-based non-invasive lithium drug monitoring: A proof-of-concept study for wearable sensing

Mona N Sweilam, Sarah Cordery, Stella Totti, Eirini G Velliou, Paola Campagnolo, John R Varcoe, Begona Delgado-Charro, Carol Crean

Research output: Contribution to journalArticle

Abstract

Flexible wearable chemical sensors are emerging tools which target diagnosis and monitoring of medical conditions. One of the potential applications of wearable chemical sensors is therapeutic drug monitoring for drugs that have a narrow therapeutic range such as lithium. We have investigated the possibility of developing a fibre- based device for non-invasive lithium drug monitoring in interstitial fluid. A flexible cotton-based lithium sensor was coupled with a carbon fibre-based reference electrode to obtain a potentiometric device. In vitro reverse iontophoresis experiments were performed to extract Liþ from under porcine skin by applying a current density of 0.4 mA cm 2 via two electrodes. Carbon fibre-based reverse iontophoresis electrodes were fabricated and used instead of a conventional silver wire-based version and comparable results were obtained. The fibre-based Liþ sensor and reference electrodes were capable of determining the Liþ concentration in samples collected via reverse iontophoresis and the results compared well to those obtained by ion chromatography. Additionally, biocompatibility of the materials used have been tested. Promising results were obtained which confirm the possibility of monitoring lithium in interstitial fluid using a wearable sensor
Original languageEnglish
Article number 111897
Number of pages7
JournalBiosensors and Bioelectronics
Early online date16 Nov 2019
DOIs
Publication statusE-pub ahead of print - 16 Nov 2019

Cite this

Sweilam, M. N., Cordery, S., Totti, S., Velliou, E. G., Campagnolo, P., Varcoe, J. R., ... Crean, C. (2019). Textile-based non-invasive lithium drug monitoring: A proof-of-concept study for wearable sensing. Biosensors and Bioelectronics, [ 111897]. https://doi.org/10.1016/j.bios.2019.111897

Textile-based non-invasive lithium drug monitoring: A proof-of-concept study for wearable sensing. / Sweilam, Mona N; Cordery, Sarah; Totti, Stella; Velliou, Eirini G; Campagnolo, Paola; Varcoe, John R; Delgado-Charro, Begona; Crean, Carol.

In: Biosensors and Bioelectronics, 16.11.2019.

Research output: Contribution to journalArticle

Sweilam, Mona N ; Cordery, Sarah ; Totti, Stella ; Velliou, Eirini G ; Campagnolo, Paola ; Varcoe, John R ; Delgado-Charro, Begona ; Crean, Carol. / Textile-based non-invasive lithium drug monitoring: A proof-of-concept study for wearable sensing. In: Biosensors and Bioelectronics. 2019.
@article{73b857788a294c5f9248f6109bd2ef73,
title = "Textile-based non-invasive lithium drug monitoring: A proof-of-concept study for wearable sensing",
abstract = "Flexible wearable chemical sensors are emerging tools which target diagnosis and monitoring of medical conditions. One of the potential applications of wearable chemical sensors is therapeutic drug monitoring for drugs that have a narrow therapeutic range such as lithium. We have investigated the possibility of developing a fibre- based device for non-invasive lithium drug monitoring in interstitial fluid. A flexible cotton-based lithium sensor was coupled with a carbon fibre-based reference electrode to obtain a potentiometric device. In vitro reverse iontophoresis experiments were performed to extract Li{\th} from under porcine skin by applying a current density of 0.4 mA cm 2 via two electrodes. Carbon fibre-based reverse iontophoresis electrodes were fabricated and used instead of a conventional silver wire-based version and comparable results were obtained. The fibre-based Li{\th} sensor and reference electrodes were capable of determining the Li{\th} concentration in samples collected via reverse iontophoresis and the results compared well to those obtained by ion chromatography. Additionally, biocompatibility of the materials used have been tested. Promising results were obtained which confirm the possibility of monitoring lithium in interstitial fluid using a wearable sensor",
author = "Sweilam, {Mona N} and Sarah Cordery and Stella Totti and Velliou, {Eirini G} and Paola Campagnolo and Varcoe, {John R} and Begona Delgado-Charro and Carol Crean",
year = "2019",
month = "11",
day = "16",
doi = "10.1016/j.bios.2019.111897",
language = "English",
journal = "Biosensors and Bioelectronics",
issn = "0956-5663",
publisher = "Elsevier",

}

TY - JOUR

T1 - Textile-based non-invasive lithium drug monitoring: A proof-of-concept study for wearable sensing

AU - Sweilam, Mona N

AU - Cordery, Sarah

AU - Totti, Stella

AU - Velliou, Eirini G

AU - Campagnolo, Paola

AU - Varcoe, John R

AU - Delgado-Charro, Begona

AU - Crean, Carol

PY - 2019/11/16

Y1 - 2019/11/16

N2 - Flexible wearable chemical sensors are emerging tools which target diagnosis and monitoring of medical conditions. One of the potential applications of wearable chemical sensors is therapeutic drug monitoring for drugs that have a narrow therapeutic range such as lithium. We have investigated the possibility of developing a fibre- based device for non-invasive lithium drug monitoring in interstitial fluid. A flexible cotton-based lithium sensor was coupled with a carbon fibre-based reference electrode to obtain a potentiometric device. In vitro reverse iontophoresis experiments were performed to extract Liþ from under porcine skin by applying a current density of 0.4 mA cm 2 via two electrodes. Carbon fibre-based reverse iontophoresis electrodes were fabricated and used instead of a conventional silver wire-based version and comparable results were obtained. The fibre-based Liþ sensor and reference electrodes were capable of determining the Liþ concentration in samples collected via reverse iontophoresis and the results compared well to those obtained by ion chromatography. Additionally, biocompatibility of the materials used have been tested. Promising results were obtained which confirm the possibility of monitoring lithium in interstitial fluid using a wearable sensor

AB - Flexible wearable chemical sensors are emerging tools which target diagnosis and monitoring of medical conditions. One of the potential applications of wearable chemical sensors is therapeutic drug monitoring for drugs that have a narrow therapeutic range such as lithium. We have investigated the possibility of developing a fibre- based device for non-invasive lithium drug monitoring in interstitial fluid. A flexible cotton-based lithium sensor was coupled with a carbon fibre-based reference electrode to obtain a potentiometric device. In vitro reverse iontophoresis experiments were performed to extract Liþ from under porcine skin by applying a current density of 0.4 mA cm 2 via two electrodes. Carbon fibre-based reverse iontophoresis electrodes were fabricated and used instead of a conventional silver wire-based version and comparable results were obtained. The fibre-based Liþ sensor and reference electrodes were capable of determining the Liþ concentration in samples collected via reverse iontophoresis and the results compared well to those obtained by ion chromatography. Additionally, biocompatibility of the materials used have been tested. Promising results were obtained which confirm the possibility of monitoring lithium in interstitial fluid using a wearable sensor

U2 - 10.1016/j.bios.2019.111897

DO - 10.1016/j.bios.2019.111897

M3 - Article

JO - Biosensors and Bioelectronics

JF - Biosensors and Bioelectronics

SN - 0956-5663

M1 - 111897

ER -