Templated dynamic synthesis of a [3]catenane

Fabien B L Cougnon; Nicholas A Jenkins; G Dan Pantoș; Jeremy K M Sanders

doi:10.1002/anie.201106885

Templated dynamic synthesis of a [3]catenane

Fabien B L Cougnon, Nicholas A Jenkins, G Dan Pantoș, Jeremy K M Sanders

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

102 Citations (SciVal)

Abstract

The self-assembly of a water-soluble [3]catenane from a library composed of two linear building blocks, both terminated by cysteine components, is promoted either by a high salt concentration or by the presence of spermine. The spermine-templated synthesis of the [3]catenane shows that such structures can exhibit strong binding interactions with a biologically relevant target in water under near-physiological conditions.

Original language	English
Pages (from-to)	1443-1447
Number of pages	5
Journal	Angewandte Chemie International Edition
Volume	51
Issue number	6
DOIs	https://doi.org/10.1002/anie.201106885
Publication status	Published - 6 Feb 2012

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title = "Templated dynamic synthesis of a [3]catenane",

abstract = "The self-assembly of a water-soluble [3]catenane from a library composed of two linear building blocks, both terminated by cysteine components, is promoted either by a high salt concentration or by the presence of spermine. The spermine-templated synthesis of the [3]catenane shows that such structures can exhibit strong binding interactions with a biologically relevant target in water under near-physiological conditions.",

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AU - Pantoș, G Dan

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AB - The self-assembly of a water-soluble [3]catenane from a library composed of two linear building blocks, both terminated by cysteine components, is promoted either by a high salt concentration or by the presence of spermine. The spermine-templated synthesis of the [3]catenane shows that such structures can exhibit strong binding interactions with a biologically relevant target in water under near-physiological conditions.

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JO - Angewandte Chemie International Edition

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Templated dynamic synthesis of a [3]catenane

Abstract

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