Templated dynamic synthesis of a [3]catenane

Fabien B L Cougnon, Nicholas A Jenkins, G Dan Pantoș, Jeremy K M Sanders

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

The self-assembly of a water-soluble [3]catenane from a library composed of two linear building blocks, both terminated by cysteine components, is promoted either by a high salt concentration or by the presence of spermine. The spermine-templated synthesis of the [3]catenane shows that such structures can exhibit strong binding interactions with a biologically relevant target in water under near-physiological conditions.
Original languageEnglish
Pages (from-to)1443-1447
Number of pages5
JournalAngewandte Chemie-International Edition
Volume51
Issue number6
DOIs
Publication statusPublished - 6 Feb 2012

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