Templated dynamic synthesis of a [3]catenane

Fabien B L Cougnon, Nicholas A Jenkins, G Dan Pantoș, Jeremy K M Sanders

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

The self-assembly of a water-soluble [3]catenane from a library composed of two linear building blocks, both terminated by cysteine components, is promoted either by a high salt concentration or by the presence of spermine. The spermine-templated synthesis of the [3]catenane shows that such structures can exhibit strong binding interactions with a biologically relevant target in water under near-physiological conditions.
Original languageEnglish
Pages (from-to)1443-1447
Number of pages5
JournalAngewandte Chemie-International Edition
Volume51
Issue number6
DOIs
Publication statusPublished - 6 Feb 2012

Fingerprint

Spermine
Water
Libraries
Cysteine
Salts
catenane

Cite this

Templated dynamic synthesis of a [3]catenane. / Cougnon, Fabien B L; Jenkins, Nicholas A; Pantoș, G Dan; Sanders, Jeremy K M.

In: Angewandte Chemie-International Edition, Vol. 51, No. 6, 06.02.2012, p. 1443-1447.

Research output: Contribution to journalArticle

Cougnon, Fabien B L ; Jenkins, Nicholas A ; Pantoș, G Dan ; Sanders, Jeremy K M. / Templated dynamic synthesis of a [3]catenane. In: Angewandte Chemie-International Edition. 2012 ; Vol. 51, No. 6. pp. 1443-1447.
@article{a4a2016824614fcbb3900483b54915a6,
title = "Templated dynamic synthesis of a [3]catenane",
abstract = "The self-assembly of a water-soluble [3]catenane from a library composed of two linear building blocks, both terminated by cysteine components, is promoted either by a high salt concentration or by the presence of spermine. The spermine-templated synthesis of the [3]catenane shows that such structures can exhibit strong binding interactions with a biologically relevant target in water under near-physiological conditions.",
author = "Cougnon, {Fabien B L} and Jenkins, {Nicholas A} and Pantoș, {G Dan} and Sanders, {Jeremy K M}",
year = "2012",
month = "2",
day = "6",
doi = "10.1002/anie.201106885",
language = "English",
volume = "51",
pages = "1443--1447",
journal = "Angewandte Chemie-International Edition",
issn = "1433-7851",
publisher = "WILEY-V C H VERLAG GMBH",
number = "6",

}

TY - JOUR

T1 - Templated dynamic synthesis of a [3]catenane

AU - Cougnon, Fabien B L

AU - Jenkins, Nicholas A

AU - Pantoș, G Dan

AU - Sanders, Jeremy K M

PY - 2012/2/6

Y1 - 2012/2/6

N2 - The self-assembly of a water-soluble [3]catenane from a library composed of two linear building blocks, both terminated by cysteine components, is promoted either by a high salt concentration or by the presence of spermine. The spermine-templated synthesis of the [3]catenane shows that such structures can exhibit strong binding interactions with a biologically relevant target in water under near-physiological conditions.

AB - The self-assembly of a water-soluble [3]catenane from a library composed of two linear building blocks, both terminated by cysteine components, is promoted either by a high salt concentration or by the presence of spermine. The spermine-templated synthesis of the [3]catenane shows that such structures can exhibit strong binding interactions with a biologically relevant target in water under near-physiological conditions.

UR - http://www.scopus.com/inward/record.url?scp=84856501031&partnerID=8YFLogxK

UR - http://dx.doi.org/10.1002/anie.201106885

U2 - 10.1002/anie.201106885

DO - 10.1002/anie.201106885

M3 - Article

VL - 51

SP - 1443

EP - 1447

JO - Angewandte Chemie-International Edition

JF - Angewandte Chemie-International Edition

SN - 1433-7851

IS - 6

ER -