Tel/PDGFR beta inhibits self-renewal and directs myelomonocytic differentiation of ES cells

E Dobbin, P M Corrigan, C P Walsh, Melanie J Welham, R W Freeburn, H Wheadon

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The leukemic oncogene Tel/PDGFR beta, was inducibly expressed in embryonic stem (ES) cells and the phenotypic and molecular changes occurring during hematopoietic differentiation investigated. Expression of Tel/PDGFR beta resulted in an inability of ES cells to self-renew and caused a significant increase in myelopoiesis with a corresponding decrease in erythropoiesis. Analysis of gene expression patterns indicated a dramatic alteration in the levels of genes associated with self-renewal and differentiation, especially myelomonocytic genes in Tel/PDGFR beta-expressing cells. This study indicates Tel/PDGFR beta drives myelopoiesis by altering expression of genes involved in hematopoiesis and demonstrates the potential of this stem cell system to study oncogene-induced pathogenesis.
Original languageEnglish
Pages (from-to)1554-1564
Number of pages11
JournalLeukemia Research
Volume32
Issue number10
DOIs
Publication statusPublished - 2008

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