Taxonomic signatures of cause-specific mortality risk in human gut microbiome

Aaro Salosensaari; Ville Laitinen; Aki S Havulinna; Guillaume Meric; Susan Cheng; Markus Perola; Liisa Valsta; Georg Alfthan; Michael Inouye; Jeramie D Watrous; Tao Long; Rodolfo A Salido; Karenina Sanders; Caitriona Brennan; Gregory C Humphrey; Jon G Sanders; Mohit Jain; Pekka Jousilahti; Veikko Salomaa; Rob Knight; Leo Lahti; Teemu Niiranen

doi:10.1038/s41467-021-22962-y

Taxonomic signatures of cause-specific mortality risk in human gut microbiome

Aaro Salosensaari, Ville Laitinen, Aki S Havulinna, Guillaume Meric, Susan Cheng, Markus Perola, Liisa Valsta, Georg Alfthan, Michael Inouye, Jeramie D Watrous, Tao Long, Rodolfo A Salido, Karenina Sanders, Caitriona Brennan, Gregory C Humphrey, Jon G Sanders, Mohit Jain, Pekka Jousilahti, Veikko Salomaa, Rob KnightLeo Lahti, Teemu Niiranen

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

109 Citations (SciVal)

Abstract

The collection of fecal material and developments in sequencing technologies have enabled standardised and non-invasive gut microbiome profiling. Microbiome composition from several large cohorts have been cross-sectionally linked to various lifestyle factors and diseases. In spite of these advances, prospective associations between microbiome composition and health have remained uncharacterised due to the lack of sufficiently large and representative population cohorts with comprehensive follow-up data. Here, we analyse the long-term association between gut microbiome variation and mortality in a well-phenotyped and representative population cohort from Finland (n = 7211). We report robust taxonomic and functional microbiome signatures related to the Enterobacteriaceae family that are associated with mortality risk during a 15-year follow-up. Our results extend previous cross-sectional studies, and help to establish the basis for examining long-term associations between human gut microbiome composition, incident outcomes, and general health status.

Original language	English
Pages (from-to)	2671
Journal	Nature Communications
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41467-021-22962-y
Publication status	Published - 11 May 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adolescent
Adult
Aged
Cause of Death/trends
Cohort Studies
Cross-Sectional Studies
Enterobacteriaceae/classification
Feces/microbiology
Female
Finland
Gastrointestinal Microbiome/genetics
Humans
Male
Middle Aged
Population Surveillance/methods
RNA, Ribosomal, 16S/genetics
Risk Factors
Young Adult

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10.1038/s41467-021-22962-yLicence: CC BY

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Salosensaari, A., Laitinen, V., Havulinna, A. S., Meric, G., Cheng, S., Perola, M., Valsta, L., Alfthan, G., Inouye, M., Watrous, J. D., Long, T., Salido, R. A., Sanders, K., Brennan, C., Humphrey, G. C., Sanders, J. G., Jain, M., Jousilahti, P., Salomaa, V., ... Niiranen, T. (2021). Taxonomic signatures of cause-specific mortality risk in human gut microbiome. Nature Communications, 12(1), 2671. https://doi.org/10.1038/s41467-021-22962-y

Salosensaari, A, Laitinen, V, Havulinna, AS, Meric, G, Cheng, S, Perola, M, Valsta, L, Alfthan, G, Inouye, M, Watrous, JD, Long, T, Salido, RA, Sanders, K, Brennan, C, Humphrey, GC, Sanders, JG, Jain, M, Jousilahti, P, Salomaa, V, Knight, R, Lahti, L & Niiranen, T 2021, 'Taxonomic signatures of cause-specific mortality risk in human gut microbiome', Nature Communications, vol. 12, no. 1, pp. 2671. https://doi.org/10.1038/s41467-021-22962-y

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AU - Jain, Mohit

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Taxonomic signatures of cause-specific mortality risk in human gut microbiome

Abstract

UN SDGs

Keywords

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