Taxane diterpenes 1. Control of relative and absolute stereochemistry in intramolecular pyrylium ylide-alkene cyclizations for the synthesis of taxol precursors

W.E. Bauta, J. Booth, M.E. Bos, M. DeLuca, L. Diorazio, T.J. Donohoe, C. Frost, N. Magnus, P. Magnus, J. Mendoza, P. Pye, J.G. Tarrant, S. Thom, F. Ujjainwalla

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Abstract

Intramolecular pyrylium ylide-alkene cyclizations provide control of the absolute stereochemistry at the crucial C-19 angular methyl group, and leads to bicyclo[5.4.03,8]undecenones that contain the structural elements of the B/C rings of the taxanes.

Original languageEnglish
Pages (from-to)14081-14102
Number of pages22
JournalTetrahedron
Volume52
Issue number45
DOIs
Publication statusPublished - 4 Nov 1996

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