Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers

Alexander Howard; Jodie Bojko; Benjamin Flynn; Sophie Bowen; Ute Jungwirth; Gernot Walko

doi:10.1111/exd.14655

Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers

Alexander Howard, Jodie Bojko, Benjamin Flynn, Sophie Bowen, Ute Jungwirth, Gernot Walko

Research output: Contribution to journal › Review article › peer-review

2 Citations (SciVal)

Abstract

Skin cancers are by far the most frequently diagnosed human cancers. The closely related transcriptional co-regulator proteins YAP and TAZ (WWTR1) have emerged as important drivers of tumour initiation, progression and metastasis in melanoma and non-melanoma skin cancers. YAP/TAZ serve as an essential signalling hub by integrating signals from multiple upstream pathways. In this review, we summarize the roles of YAP/TAZ in skin physiology and tumorigenesis and discuss recent efforts of therapeutic interventions that target YAP/TAZ in in both preclinical and clinical settings, as well as their prospects for use as skin cancer treatments.

Original language	English
Pages (from-to)	1477-1499
Number of pages	23
Journal	Experimental Dermatology
Volume	31
Issue number	10
Early online date	1 Aug 2022
DOIs	https://doi.org/10.1111/exd.14655
Publication status	Published - 31 Oct 2022

Keywords

Hippo signalling
basal cell carcinoma
epidermis
melanoma
skin cancer
squamous cell carcinoma

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Dermatology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/exd.14655Licence: CC BY

Cite this

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title = "Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers",

abstract = "Skin cancers are by far the most frequently diagnosed human cancers. The closely related transcriptional co-regulator proteins YAP and TAZ (WWTR1) have emerged as important drivers of tumour initiation, progression and metastasis in melanoma and non-melanoma skin cancers. YAP/TAZ serve as an essential signalling hub by integrating signals from multiple upstream pathways. In this review, we summarize the roles of YAP/TAZ in skin physiology and tumorigenesis and discuss recent efforts of therapeutic interventions that target YAP/TAZ in in both preclinical and clinical settings, as well as their prospects for use as skin cancer treatments.",

keywords = "Hippo signalling, basal cell carcinoma, epidermis, melanoma, skin cancer, squamous cell carcinoma",

author = "Alexander Howard and Jodie Bojko and Benjamin Flynn and Sophie Bowen and Ute Jungwirth and Gernot Walko",

note = "British Skin Foundation (GrantNumber(s): 036/S/18; Grant recipient(s): Gernot Walko) Academy of Medical Sciences (GrantNumber(s): SBF005\1005; Grant recipient(s): Gernot Walko) Biotechnology and Biological Sciences Research Council (GrantNumber(s): BB/T012978/1; Grant recipient(s): Gernot Walko)",

year = "2022",

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doi = "10.1111/exd.14655",

language = "English",

volume = "31",

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T1 - Targeting the Hippo/YAP/TAZ signalling pathway

T2 - Novel opportunities for therapeutic interventions into skin cancers

AU - Howard, Alexander

AU - Bojko, Jodie

AU - Flynn, Benjamin

AU - Bowen, Sophie

AU - Jungwirth, Ute

AU - Walko, Gernot

N1 - British Skin Foundation (GrantNumber(s): 036/S/18; Grant recipient(s): Gernot Walko) Academy of Medical Sciences (GrantNumber(s): SBF005\1005; Grant recipient(s): Gernot Walko) Biotechnology and Biological Sciences Research Council (GrantNumber(s): BB/T012978/1; Grant recipient(s): Gernot Walko)

PY - 2022/10/31

Y1 - 2022/10/31

N2 - Skin cancers are by far the most frequently diagnosed human cancers. The closely related transcriptional co-regulator proteins YAP and TAZ (WWTR1) have emerged as important drivers of tumour initiation, progression and metastasis in melanoma and non-melanoma skin cancers. YAP/TAZ serve as an essential signalling hub by integrating signals from multiple upstream pathways. In this review, we summarize the roles of YAP/TAZ in skin physiology and tumorigenesis and discuss recent efforts of therapeutic interventions that target YAP/TAZ in in both preclinical and clinical settings, as well as their prospects for use as skin cancer treatments.

AB - Skin cancers are by far the most frequently diagnosed human cancers. The closely related transcriptional co-regulator proteins YAP and TAZ (WWTR1) have emerged as important drivers of tumour initiation, progression and metastasis in melanoma and non-melanoma skin cancers. YAP/TAZ serve as an essential signalling hub by integrating signals from multiple upstream pathways. In this review, we summarize the roles of YAP/TAZ in skin physiology and tumorigenesis and discuss recent efforts of therapeutic interventions that target YAP/TAZ in in both preclinical and clinical settings, as well as their prospects for use as skin cancer treatments.

KW - Hippo signalling

KW - basal cell carcinoma

KW - epidermis

KW - melanoma

KW - skin cancer

KW - squamous cell carcinoma

UR - http://www.scopus.com/inward/record.url?scp=85135834869&partnerID=8YFLogxK

U2 - 10.1111/exd.14655

DO - 10.1111/exd.14655

M3 - Review article

SN - 1600-0625

VL - 31

SP - 1477

EP - 1499

JO - Experimental Dermatology

JF - Experimental Dermatology

IS - 10

ER -

Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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