Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers

Alexander Howard, Jodie Bojko, Benjamin Flynn, Sophie Bowen, Ute Jungwirth, Gernot Walko

Research output: Contribution to journalReview articlepeer-review

8 Citations (SciVal)

Abstract

Skin cancers are by far the most frequently diagnosed human cancers. The closely related transcriptional co-regulator proteins YAP and TAZ (WWTR1) have emerged as important drivers of tumour initiation, progression and metastasis in melanoma and non-melanoma skin cancers. YAP/TAZ serve as an essential signalling hub by integrating signals from multiple upstream pathways. In this review, we summarize the roles of YAP/TAZ in skin physiology and tumorigenesis and discuss recent efforts of therapeutic interventions that target YAP/TAZ in in both preclinical and clinical settings, as well as their prospects for use as skin cancer treatments.

Original languageEnglish
Pages (from-to)1477-1499
Number of pages23
JournalExperimental Dermatology
Volume31
Issue number10
Early online date1 Aug 2022
DOIs
Publication statusPublished - 31 Oct 2022

Bibliographical note

British Skin Foundation (GrantNumber(s): 036/S/18; Grant recipient(s): Gernot Walko)
Academy of Medical Sciences (GrantNumber(s): SBF005\1005; Grant recipient(s): Gernot Walko)
Biotechnology and Biological Sciences Research Council (GrantNumber(s): BB/T012978/1; Grant recipient(s): Gernot Walko)

Keywords

  • Hippo signalling
  • basal cell carcinoma
  • epidermis
  • melanoma
  • skin cancer
  • squamous cell carcinoma

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

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