Projects per year
Abstract
Skin cancers are by far the most frequently diagnosed human cancers. The closely related transcriptional co-regulator proteins YAP and TAZ (WWTR1) have emerged as important drivers of tumour initiation, progression and metastasis in melanoma and non-melanoma skin cancers. YAP/TAZ serve as an essential signalling hub by integrating signals from multiple upstream pathways. In this review, we summarize the roles of YAP/TAZ in skin physiology and tumorigenesis and discuss recent efforts of therapeutic interventions that target YAP/TAZ in in both preclinical and clinical settings, as well as their prospects for use as skin cancer treatments.
Original language | English |
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Pages (from-to) | 1477-1499 |
Number of pages | 23 |
Journal | Experimental Dermatology |
Volume | 31 |
Issue number | 10 |
Early online date | 1 Aug 2022 |
DOIs | |
Publication status | Published - 31 Oct 2022 |
Bibliographical note
British Skin Foundation (GrantNumber(s): 036/S/18; Grant recipient(s): Gernot Walko)Academy of Medical Sciences (GrantNumber(s): SBF005\1005; Grant recipient(s): Gernot Walko)
Biotechnology and Biological Sciences Research Council (GrantNumber(s): BB/T012978/1; Grant recipient(s): Gernot Walko)
Keywords
- Hippo signalling
- basal cell carcinoma
- epidermis
- melanoma
- skin cancer
- squamous cell carcinoma
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Dermatology
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Dive into the research topics of 'Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers'. Together they form a unique fingerprint.Projects
- 2 Finished
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The transcriptional control of human epidermal stemness.
Walko, G. (PI)
Biotechnology and Biological Sciences Research Council
1/03/21 → 29/02/24
Project: Research council
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Targeting YAP/TAZ as a novel therapeutic strategy in cutaneous squamous cell carcinoma.
Walko, G. (PI) & Catalan, S. (Researcher)
The Academy of Medical Sciences
1/12/20 → 30/04/23
Project: UK charity