Targeted photothermal release of antibiotics by a graphene nanoribbon-based supramolecular glycomaterial

Ying Shang, Sheng Zhang, Hui-Qi Gan, Kai-Cheng Yan, Fugui Xu, Yiyong Mai, Daijie Chen, Xi-le Hu, Lei Zou, Tony D. James, Xiao-Peng He

Research output: Contribution to journalArticlepeer-review

1 Citation (SciVal)

Abstract

Here, we report the simple construction of a supramolecular glycomaterial for the targeted delivery of antibiotics to P. aeruginosa in a photothermally-controlled manner. A galactose-pyrene conjugate (Gal-pyr) was developed to self-assemble with graphene nanoribbon-based nanowires via π–π stacking to produce a supramolecular glycomaterial, which exhibits a 1250-fold enhanced binding avidity toward a galactose-selective lectin when compared to Gal-pyr. The as-prepared glycomaterial when loaded with an antibiotic that acts as an inhibitor of the bacterial folic acid biosynthetic pathway eradicated P. aeruginosa-derived biofilms under near-infrared light irradiation due to the strong photothermal effect of the nanowires accelerating antibiotic release.
Original languageEnglish
Pages (from-to)1094-1097
JournalChemical Communications
Volume59
Issue number8
Early online date10 Jan 2023
DOIs
Publication statusPublished - 25 Jan 2023

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