Targeted multimodal theranostics: via biorecognition controlled aggregation of metallic nanoparticle composites

Xi Le Hu, Yi Zang, Jia Li, Guo Rong Chen, Tony D. James, Xiao Peng He, He Tian

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

We have developed a theranostic nanocomposite of metallic nanoparticles that uses two distinct fluorescence mechanisms: Förster Resonance Energy Transfer (FRET) and Metal-Enhanced Fluorescence (MEF) controlled by ligand-receptor interaction. Supramolecular assembly of the fluorophore-labeled glycoligands to cyclodextrin-capped gold nanoparticles produces a nanocomposite with a quenched fluorescence due to FRET from the fluorophore to the proximal particle. Subsequently, interaction with a selective protein receptor leads to an aggregation of the composite, reactivating the fluorescence by MEF from the distal metallic particles to fluorophores encapsulated in the aggregates. The aggregation also causes a red-shift in absorbance of the composite, thereby enhancing the production of reactive oxygen species (ROS) on red-light irradiation. Our nanocomposite has proven suitable for targeted cancer cell imaging as well as multimode therapy using both the photodynamic and drug delivery properties of the composite.

Original languageEnglish
Pages (from-to)4004-4008
Number of pages5
JournalChemical Science
Volume7
Issue number7
DOIs
Publication statusPublished - 1 Jul 2016

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