Targeted delivery of maytansine to liver cancer cells via galactose-modified supramolecular two-dimensional glycomaterial

Hai Na Xie; Yu Yuan Chen; Guo Biao Zhu; Hai Hao Han; Xi Le Hu; Zhi Qiang Pan; Yi Zang; Dong Hao Xie; Xiao Peng He; Jia Li; Tony D. James

doi:10.1039/d1cc06809a

Targeted delivery of maytansine to liver cancer cells via galactose-modified supramolecular two-dimensional glycomaterial

Hai Na Xie, Yu Yuan Chen, Guo Biao Zhu, Hai Hao Han, Xi Le Hu, Zhi Qiang Pan, Yi Zang, Dong Hao Xie, Xiao Peng He, Jia Li, Tony D. James

Research output: Contribution to journal › Article › peer-review

7 Citations (SciVal)

Abstract

A two-dimensional (2D) glycomaterial for targeted delivery of maytansine to liver cancer cells was developed. Host-guest interaction between a galactosyl dye and human serum albumin (HSA) produces supramolecular galactoside-HSA conjugates, which are then used to coat 2D MoS₂. The 2D glycomaterial was shown to be capable of the targeted delivery of maytansine to a liver cancer cell line that highly expresses a galactose receptor, resulting in greater cytotoxicity than maytansine alone.

Original language	English
Pages (from-to)	5029-5032
Number of pages	4
Journal	Chemical Communications
Volume	58
Early online date	19 Mar 2022
DOIs	https://doi.org/10.1039/d1cc06809a
Publication status	Published - 5 Apr 2022

Bibliographical note

X.-P. H. thanks the National Natural Science Foundation of China (No. 21788102, 91853201), the Shanghai Science and Technology Committee (No. 19410712600), the Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX03), the Fundamental Research Funds for the Central Universities (222201717003) and the Programme of Introducing Talents of Discipline to Universities (B16017) for financial support. H.-H. H. thanks the National Natural Science Foundation of China (No. 22107029) and Project funded by China Postdoctoral Science Foundation (No. 2020M681196). T. D. J. wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01).

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/d1cc06809aLicence: CC BY

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abstract = "A two-dimensional (2D) glycomaterial for targeted delivery of maytansine to liver cancer cells was developed. Host-guest interaction between a galactosyl dye and human serum albumin (HSA) produces supramolecular galactoside-HSA conjugates, which are then used to coat 2D MoS2. The 2D glycomaterial was shown to be capable of the targeted delivery of maytansine to a liver cancer cell line that highly expresses a galactose receptor, resulting in greater cytotoxicity than maytansine alone.",

author = "Xie, {Hai Na} and Chen, {Yu Yuan} and Zhu, {Guo Biao} and Han, {Hai Hao} and Hu, {Xi Le} and Pan, {Zhi Qiang} and Yi Zang and Xie, {Dong Hao} and He, {Xiao Peng} and Jia Li and James, {Tony D.}",

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AU - Xie, Hai Na

AU - Chen, Yu Yuan

AU - Zhu, Guo Biao

AU - Han, Hai Hao

AU - Hu, Xi Le

AU - Pan, Zhi Qiang

AU - Zang, Yi

AU - Xie, Dong Hao

AU - He, Xiao Peng

AU - Li, Jia

AU - James, Tony D.

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AB - A two-dimensional (2D) glycomaterial for targeted delivery of maytansine to liver cancer cells was developed. Host-guest interaction between a galactosyl dye and human serum albumin (HSA) produces supramolecular galactoside-HSA conjugates, which are then used to coat 2D MoS2. The 2D glycomaterial was shown to be capable of the targeted delivery of maytansine to a liver cancer cell line that highly expresses a galactose receptor, resulting in greater cytotoxicity than maytansine alone.

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Targeted delivery of maytansine to liver cancer cells via galactose-modified supramolecular two-dimensional glycomaterial

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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