Targeted delivery of maytansine to liver cancer cells via galactose-modified supramolecular two-dimensional glycomaterial

Hai Na Xie, Yu Yuan Chen, Guo Biao Zhu, Hai Hao Han, Xi Le Hu, Zhi Qiang Pan, Yi Zang, Dong Hao Xie, Xiao Peng He, Jia Li, Tony D. James

Research output: Contribution to journalArticlepeer-review

Abstract

A two-dimensional (2D) glycomaterial for targeted delivery of maytansine to liver cancer cells was developed. Host-guest interaction between a galactosyl dye and human serum albumin (HSA) produces supramolecular galactoside-HSA conjugates, which are then used to coat 2D MoS2. The 2D glycomaterial was shown to be capable of the targeted delivery of maytansine to a liver cancer cell line that highly expresses a galactose receptor, resulting in greater cytotoxicity than maytansine alone.

Original languageEnglish
Pages (from-to)5029-5032
Number of pages4
JournalChemical Communications
Volume58
Early online date19 Mar 2022
DOIs
Publication statusPublished - 5 Apr 2022

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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