Tandem and domino catalytic strategies for enantioselective synthesis

C.J. Chapman, C.G. Frost

Research output: Contribution to journalArticlepeer-review

454 Citations (SciVal)


Catalytic asymmetric methodologies provide versatile routes to many complex molecules through expedient and often elegant processes. This review summarises the work on the development and application of tandem and domino catalysed reactions within enantioselective organic synthesis. 1 Introduction 2 Transition-Metal-Catalysed Processes 2.1 Processes Involving Michael Additions 2.2 Hydroformylations 2.3 Heck Reactions 2.4 Allylic Substitutions 2.5 Processes Involving Pericyclic Reactions 2.6 Hydrogenations 2.7 Aldol Reactions 2.8 Metathesis Reactions 2.9 Processes Involving Epoxide Formation 2.10 Miscellaneous Transition-Metal-Catalysed Processes 3 Chiral Organocatalytic Reactions 3.1 Processes Involving Michael Additions 3.2 Aldol Reactions 3.3 Mannich Reactions 3.4 Processes Involving Pericyclic Reactions 3.5 Miscellaneous Organocatalytic Processes 4 Conclusions.
Original languageEnglish
Pages (from-to)1-21
Number of pages21
Issue number1
Publication statusPublished - 4 Jan 2007


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