T-lymphocyte navigation and migration: beyond the PI3K paradigm

L Smith, A Webb, S G Ward

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The co-ordinated and directional trafficking of T-lymphocytes in lymphoid and peripheral tissues is an important process in lymphoid development, immunosurveillance and immune responses. Members of the chemokine superfamily play a key role in providing navigational cues for T-cells and chemokine receptors couple with a wide range of biochemical signals including phosphoinositide lipid metabolism, elevation of intracellular calcium levels, activation of a wide array of protein kinases as well as small GTPases. one of the most robust biochemical signals elicited by chemokines in T-lymphocytes is the activation of several members of the PI3K (phosphoinositide 3-kinase) family. In many cell systems, PI3Ks are known to contribute to several aspects of the migratory machinery, although their role in T-cell migration has been unclear and will be considered in the present paper.
Original languageEnglish
Pages (from-to)193-198
Number of pages6
JournalBiochemical Society Transactions
Volume35
Publication statusPublished - 2007

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