Synthetic tools for studying the chemical biology of InsP8

Andrew M. Riley, Huanchen Wang, Stephen B. Shears, Barry V L Potter

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)
103 Downloads (Pure)

Abstract

To synthesise stabilised mimics of InsP8, the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural and biochemical analyses of their interactions with enzymes of InsP8 metabolism.

Original languageEnglish
Pages (from-to)12605-12608
Number of pages4
JournalChemical Communications
Volume51
Issue number63
Early online date3 Jul 2015
DOIs
Publication statusPublished - 14 Aug 2015

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