Synthetic tools for studying the chemical biology of InsP8

Andrew M. Riley; Huanchen Wang; Stephen B. Shears; Barry V L Potter

doi:10.1039/c5cc05017k

Synthetic tools for studying the chemical biology of InsP₈

Andrew M. Riley, Huanchen Wang, Stephen B. Shears, Barry V L Potter

Department of Life Sciences

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Abstract

To synthesise stabilised mimics of InsP₈, the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural and biochemical analyses of their interactions with enzymes of InsP₈ metabolism.

Original language	English
Pages (from-to)	12605-12608
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	63
Early online date	3 Jul 2015
DOIs	https://doi.org/10.1039/c5cc05017k
Publication status	Published - 14 Aug 2015

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10.1039/c5cc05017k

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title = "Synthetic tools for studying the chemical biology of InsP8",

abstract = "To synthesise stabilised mimics of InsP8, the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural and biochemical analyses of their interactions with enzymes of InsP8 metabolism.",

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AU - Wang, Huanchen

AU - Shears, Stephen B.

AU - Potter, Barry V L

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N2 - To synthesise stabilised mimics of InsP8, the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural and biochemical analyses of their interactions with enzymes of InsP8 metabolism.

AB - To synthesise stabilised mimics of InsP8, the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural and biochemical analyses of their interactions with enzymes of InsP8 metabolism.

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Synthetic tools for studying the chemical biology of InsP₈

Abstract

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