Synthetic tools for studying the chemical biology of InsP8

Andrew M. Riley, Huanchen Wang, Stephen B. Shears, Barry V L Potter

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)
136 Downloads (Pure)


To synthesise stabilised mimics of InsP8, the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural and biochemical analyses of their interactions with enzymes of InsP8 metabolism.

Original languageEnglish
Pages (from-to)12605-12608
Number of pages4
JournalChemical Communications
Issue number63
Early online date3 Jul 2015
Publication statusPublished - 14 Aug 2015

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