Abstract
To synthesise stabilised mimics of InsP8, the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural and biochemical analyses of their interactions with enzymes of InsP8 metabolism.
Original language | English |
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Pages (from-to) | 12605-12608 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 51 |
Issue number | 63 |
Early online date | 3 Jul 2015 |
DOIs | |
Publication status | Published - 14 Aug 2015 |