Synthesis of ureas in the bio-alternative solvent Cyrene

Liam Mistry; Kopano Mapesa; Thomas W. Bousfield; Jason E. Camp

doi:10.1039/C7GC00908A

Synthesis of ureas in the bio-alternative solvent Cyrene

Liam Mistry, Kopano Mapesa, Thomas W. Bousfield, Jason E. Camp

Department of Chemistry

University of Huddersfield

Research output: Contribution to journal › Article › peer-review

84 Citations (SciVal)

Abstract

Cyrene as a bio-alternative solvent: a highly efficient, waste minimizing protocol for the synthesis of ureas from isocyanates and secondary amines in the bio-available solvent Cyrene is reported. This method eliminated the use of toxic solvents, such as DMF, and established a simple work-up procedure for removal of the Cyrene, which led to a 28-fold increase in molar efficiency vs. industrial std. protocols. [on SciFinder(R)]

Original language	English
Pages (from-to)	2123-2128
Number of pages	6
Journal	Green Chemistry
Volume	19
Issue number	9
Early online date	24 Apr 2017
DOIs	https://doi.org/10.1039/C7GC00908A
Publication status	Published - 7 May 2017

Bibliographical note

M1 - Copyright (C) 2018 American Chemical Society (ACS). All Rights Reserved.

CAPLUS AN 2017:641698(Journal; Online Computer File)

Keywords

isocyanate secondary amine coupling cyrene
arylurea prepn

Access to Document

10.1039/C7GC00908A

Cite this

@article{de35508a7f48420a9286216ede4e0501,

title = "Synthesis of ureas in the bio-alternative solvent Cyrene",

abstract = "Cyrene as a bio-alternative solvent: a highly efficient, waste minimizing protocol for the synthesis of ureas from isocyanates and secondary amines in the bio-available solvent Cyrene is reported. This method eliminated the use of toxic solvents, such as DMF, and established a simple work-up procedure for removal of the Cyrene, which led to a 28-fold increase in molar efficiency vs. industrial std. protocols. [on SciFinder(R)]",

keywords = "isocyanate secondary amine coupling cyrene, arylurea prepn",

author = "Liam Mistry and Kopano Mapesa and Bousfield, {Thomas W.} and Camp, {Jason E.}",

year = "2017",

month = may,

day = "7",

doi = "10.1039/C7GC00908A",

language = "English",

volume = "19",

pages = "2123--2128",

journal = "Green Chemistry",

issn = "1463-9262",

publisher = "Royal Society of Chemistry",

number = "9",

}

TY - JOUR

T1 - Synthesis of ureas in the bio-alternative solvent Cyrene

AU - Mistry, Liam

AU - Mapesa, Kopano

AU - Bousfield, Thomas W.

AU - Camp, Jason E.

PY - 2017/5/7

Y1 - 2017/5/7

N2 - Cyrene as a bio-alternative solvent: a highly efficient, waste minimizing protocol for the synthesis of ureas from isocyanates and secondary amines in the bio-available solvent Cyrene is reported. This method eliminated the use of toxic solvents, such as DMF, and established a simple work-up procedure for removal of the Cyrene, which led to a 28-fold increase in molar efficiency vs. industrial std. protocols. [on SciFinder(R)]

AB - Cyrene as a bio-alternative solvent: a highly efficient, waste minimizing protocol for the synthesis of ureas from isocyanates and secondary amines in the bio-available solvent Cyrene is reported. This method eliminated the use of toxic solvents, such as DMF, and established a simple work-up procedure for removal of the Cyrene, which led to a 28-fold increase in molar efficiency vs. industrial std. protocols. [on SciFinder(R)]

KW - isocyanate secondary amine coupling cyrene

KW - arylurea prepn

U2 - 10.1039/C7GC00908A

DO - 10.1039/C7GC00908A

M3 - Article

SN - 1463-9262

VL - 19

SP - 2123

EP - 2128

JO - Green Chemistry

JF - Green Chemistry

IS - 9

ER -

Synthesis of ureas in the bio-alternative solvent Cyrene

Abstract

Bibliographical note

Keywords

Access to Document

Fingerprint

Cite this