Synthesis of ureas in the bio-alternative solvent Cyrene

Liam Mistry, Kopano Mapesa, Thomas W. Bousfield, Jason E. Camp

Research output: Contribution to journalArticlepeer-review

76 Citations (SciVal)


Cyrene as a bio-alternative solvent: a highly efficient, waste minimizing protocol for the synthesis of ureas from isocyanates and secondary amines in the bio-available solvent Cyrene is reported. This method eliminated the use of toxic solvents, such as DMF, and established a simple work-up procedure for removal of the Cyrene, which led to a 28-fold increase in molar efficiency vs. industrial std. protocols. [on SciFinder(R)]
Original languageEnglish
Pages (from-to)2123-2128
Number of pages6
JournalGreen Chemistry
Issue number9
Early online date24 Apr 2017
Publication statusPublished - 7 May 2017

Bibliographical note

M1 - Copyright (C) 2018 American Chemical Society (ACS). All Rights Reserved.

CAPLUS AN 2017:641698(Journal; Online Computer File)


  • isocyanate secondary amine coupling cyrene
  • arylurea prepn


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