Abstract
Well-defined poly(N-isopropylacrylamide) (PNIPAM) polymers with an oxazolone ring at the chain end have been synthesized by combining controlled radical polymerization and thiol-Michael addition "click" chemistry. First, PNIPAM was synthesized using reversible addition-fragmentation chain transfer (RAFT) polymerization to afford polymers of controlled molecular weight and molecular weight distribution (Mn (1H NMR) = 3200 g mol -1; PDISEC = 1.05). The chain end was quantitatively converted to a thiol by aminolysis. Then, the functional monomer vinyl azlactone (VDM) was quantitatively "clicked" onto the chain end using a thiol-Michael addition reaction. The polymers were reacted with a model amine in order to demonstrate the potential of these polymers for bioconjugation.
Original language | English |
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Pages (from-to) | 1258-1260 |
Number of pages | 3 |
Journal | Polymer Chemistry |
Volume | 2 |
Issue number | 6 |
DOIs | |
Publication status | Published - 1 Jun 2011 |
ASJC Scopus subject areas
- Polymers and Plastics
- Organic Chemistry
- Biochemistry
- Biomedical Engineering
- Bioengineering