Synthesis of PLGA using a C3-symmetric Zr (IV) amine tris(phenolate) alkoxide initiator and the effects of gamma radiation on its properties

Fernando Peleias Junior, Matthew Jones, Carlos Zeituni, Maria Rostelato, Paulo Moreira Junior

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Abstract

In this paper, we report the preparation and characterisation of poly(lactic-co-glycolic) acid (PLGA) using a C3-symmetric Zr (IV) amine tris(phenolate) alkoxide initiator. Although the zirconium alkoxide initiator is slower than the most commonly used Sn(Oct)2, relatively high molecular weights were obtained at a temperature of 130° C, for a monomer to initiator ratio of 1000/1 (24 h), and 5000/1 (48 h). The degree of racemisation also depends upon the initiator used. The reactions performed with the zirconium initiator showed a higher degree of racemisation when compared to those performed with Sn(Oct)2. A slight increase in the racemisation with time was also observed. The effects of gamma-radiation on PLGA were also studied. Doses commonly applied to sterilise materials for biomedical applications were employed - 10, 18, 25 and 50 kGy. The molecular weight of all samples irradiated decreased in a dose dependent fashion - up to 56% loss for 10 kGy and 72% for 50 kGy - but are less pronounced for higher doses. Changes in thermal properties, such as melting point, glass transition temperature and enthalpy of crystallisation and fusion were also observed after irradiation.
Original languageEnglish
Pages (from-to)91-105
Number of pages1
JournalPolymer Bulletin
Volume74
Issue number1
Early online date19 May 2016
DOIs
Publication statusPublished - Jan 2017

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alkoxides
initiators
Zirconium
Gamma rays
Amines
amines
Molecular weight
gamma rays
acids
Acids
synthesis
Crystallization
Dosimetry
Melting point
Enthalpy
Fusion reactions
Thermodynamic properties
Monomers
dosage
Irradiation

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Synthesis of PLGA using a C3-symmetric Zr (IV) amine tris(phenolate) alkoxide initiator and the effects of gamma radiation on its properties. / Peleias Junior, Fernando; Jones, Matthew; Zeituni, Carlos; Rostelato, Maria; Moreira Junior, Paulo.

In: Polymer Bulletin, Vol. 74, No. 1, 01.2017, p. 91-105.

Research output: Contribution to journalArticle

Peleias Junior, Fernando ; Jones, Matthew ; Zeituni, Carlos ; Rostelato, Maria ; Moreira Junior, Paulo. / Synthesis of PLGA using a C3-symmetric Zr (IV) amine tris(phenolate) alkoxide initiator and the effects of gamma radiation on its properties. In: Polymer Bulletin. 2017 ; Vol. 74, No. 1. pp. 91-105.
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