TY - JOUR
T1 - Synthesis of N-(Methoxycarbonylthienylmethyl)thioureas and evaluation of their interaction with inducible and neuronal Nitric Oxide Synthase
AU - Suaifan, Gary
AU - Goodyer, C L M
AU - Threadgill, Michael D
PY - 2010/4/28
Y1 - 2010/4/28
N2 - Two isomeric N-(methoxycarbonylthienylmethyl)thioureas were synthesised by a sequence of radical bromination of methylthiophenecarboxylic esters, substitution with trifluoroacetamide anion, deprotection, formation of the corresponding isothiocyanates and addition of ammonia. The interaction of these new thiophene-based thioureas with inducible and neuronal nitric oxide synthase was evaluauted. These novel thienylmethylthioureas stimulated the activity of inducible Nitric Oxide Synthase (iNOS).
AB - Two isomeric N-(methoxycarbonylthienylmethyl)thioureas were synthesised by a sequence of radical bromination of methylthiophenecarboxylic esters, substitution with trifluoroacetamide anion, deprotection, formation of the corresponding isothiocyanates and addition of ammonia. The interaction of these new thiophene-based thioureas with inducible and neuronal nitric oxide synthase was evaluauted. These novel thienylmethylthioureas stimulated the activity of inducible Nitric Oxide Synthase (iNOS).
KW - stimulation
KW - thienylmethylthioureas
KW - iNOS
KW - nitric oxide synthase
UR - http://www.scopus.com/inward/record.url?scp=77952831887&partnerID=8YFLogxK
UR - http://dx.doi.org/10.3390/molecules15053121
U2 - 10.3390/molecules15053121
DO - 10.3390/molecules15053121
M3 - Article
SN - 1420-3049
VL - 15
SP - 3121
EP - 3134
JO - Molecules
JF - Molecules
IS - 5
ER -