Synthesis of N-(Methoxycarbonylthienylmethyl)thioureas and evaluation of their interaction with inducible and neuronal Nitric Oxide Synthase

Gary Suaifan, C L M Goodyer, Michael D Threadgill

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Two isomeric N-(methoxycarbonylthienylmethyl)thioureas were synthesised by a sequence of radical bromination of methylthiophenecarboxylic esters, substitution with trifluoroacetamide anion, deprotection, formation of the corresponding isothiocyanates and addition of ammonia. The interaction of these new thiophene-based thioureas with inducible and neuronal nitric oxide synthase was evaluauted. These novel thienylmethylthioureas stimulated the activity of inducible Nitric Oxide Synthase (iNOS).
Original languageEnglish
Pages (from-to)3121-3134
Number of pages14
JournalMolecules
Volume15
Issue number5
DOIs
Publication statusPublished - 28 Apr 2010

Keywords

  • stimulation
  • thienylmethylthioureas
  • iNOS
  • nitric oxide synthase

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