A nucleophilic catalysis method providing a concise synthesis of di-, tri-, and tetrasubstituted pyrroles is described. This regioselective one-pot method relies on nucleophilic catalysis of the intermol. addn. of oximes to activated alkynes and thermal rearrangement of the in situ generated O-vinyl oximes to form pyrroles that contain a functional group handle at the C3/C4 position.
- oxime stereoselective prepn
- ketone hydroxyamine hydrochloride diastereoselective condensation
- pyrrole prepn
- alkyne oxime regioselective intermol addn nucleophilic catalysis
- vinyl oxime thermal rearrangement microwave irradn