Synthesis of furans, pyrroles and pyridazines by a ruthenium-catalysed isomerisation of alkynediols and in situ cyclisation

S J Pridmore, P A Slatford, J E Taylor, M K Whittlesey, J M J Williams

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42 Citations (Scopus)

Abstract

Alkyne-1,4-diols are readily available substrates which are isomerised to 1,4-diketones using Ru(PPh3)(3)(CO)H-2/xantphos as a catalyst. In situ cyclisation into furans, pyrroles and pyridazines has been achieved under suitable conditions. (C) 2009 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)8981-8986
Number of pages6
JournalTetrahedron
Volume65
Issue number44
DOIs
Publication statusPublished - 2009

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