Synthesis of α,β-unsaturated aldehydes based on a one-pot phase-switch dehydrogenative cross-coupling of primary alcohols

Manuel G. Mura, Lidia De Luca, Maurizio Taddei, Jonathan M J Williams, Andrea Porcheddu

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

An efficient one-pot ruthenium-catalyzed hydrogen-transfer strategy for a direct access to α,β-unsaturated aldehydes has been developed. The employment of enolates prepared in situ from alcohols avoided handling unstable aldehydes and provided a very appealing route to different cinnamaldehydes substituted in position 2. A silica-grafted amine was used as phase-switch tag leading to a selective one-pot process in favor of cross-dehydrogenative coupling products.

Original languageEnglish
Pages (from-to)2586-2589
Number of pages4
JournalOrganic Letters
Volume16
Issue number10
DOIs
Publication statusPublished - 16 May 2014

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

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