Synthesis and antiproliferative activity of some 3-(pyrid-2-yl)-pyrazolines

Alexander Ciupa, Paul A. De Bank, Mary F. Mahon, Pauline J. Wood, Lorenzo Caggiano

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The synthesis and antiproliferative activity of eleven 3-(pyrid-2-yl)-pyrazolines in two cancer cell lines are reported. X-ray crystallography was obtained of the lead compound 8i which was screened in the NCI 60 human tumour cell line and displayed sub-micromolar activity. Cell cycle analysis, in vitro tubulin assay and confocal microscopy are also reported and suggest that the lead compound disrupts microtubule formation.
Original languageEnglish
Pages (from-to)956-961
Number of pages6
JournalMedChemComm
Volume4
Issue number6
Early online date23 Apr 2013
DOIs
Publication statusPublished - 1 Jun 2013

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