Synthesis and antiproliferative activity of some 3-(pyrid-2-yl)-pyrazolines

Alexander Ciupa; Paul A. De Bank; Mary F. Mahon; Pauline J. Wood; Lorenzo Caggiano

doi:10.1039/C3MD00077J

Synthesis and antiproliferative activity of some 3-(pyrid-2-yl)-pyrazolines

Alexander Ciupa, Paul A. De Bank, Mary F. Mahon, Pauline J. Wood, Lorenzo Caggiano

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Abstract

The synthesis and antiproliferative activity of eleven 3-(pyrid-2-yl)-pyrazolines in two cancer cell lines are reported. X-ray crystallography was obtained of the lead compound 8i which was screened in the NCI 60 human tumour cell line and displayed sub-micromolar activity. Cell cycle analysis, in vitro tubulin assay and confocal microscopy are also reported and suggest that the lead compound disrupts microtubule formation.

Original language	English
Pages (from-to)	956-961
Number of pages	6
Journal	MedChemComm
Volume	4
Issue number	6
Early online date	23 Apr 2013
DOIs	https://doi.org/10.1039/C3MD00077J
Publication status	Published - 1 Jun 2013

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abstract = "The synthesis and antiproliferative activity of eleven 3-(pyrid-2-yl)-pyrazolines in two cancer cell lines are reported. X-ray crystallography was obtained of the lead compound 8i which was screened in the NCI 60 human tumour cell line and displayed sub-micromolar activity. Cell cycle analysis, in vitro tubulin assay and confocal microscopy are also reported and suggest that the lead compound disrupts microtubule formation.",

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AU - Ciupa, Alexander

AU - De Bank, Paul A.

AU - Mahon, Mary F.

AU - Wood, Pauline J.

AU - Caggiano, Lorenzo

PY - 2013/6/1

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AB - The synthesis and antiproliferative activity of eleven 3-(pyrid-2-yl)-pyrazolines in two cancer cell lines are reported. X-ray crystallography was obtained of the lead compound 8i which was screened in the NCI 60 human tumour cell line and displayed sub-micromolar activity. Cell cycle analysis, in vitro tubulin assay and confocal microscopy are also reported and suggest that the lead compound disrupts microtubule formation.

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UR - http://dx.doi.org/10.1039/C3MD00077J

UR - http://people.bath.ac.uk/lc287/publications.html

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Synthesis and antiproliferative activity of some 3-(pyrid-2-yl)-pyrazolines

Abstract

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