Synthesis and antimicrobial activity of 1,3-bis-butyl-5-(4-iodophenyl)-1,3,5-triazacyclohexane

Leila Lefrada, Randolf Kohn, Souhila Malki, Wissam Mazouz, Ahcene Bouchemma, Meriem Hadjem

Research output: Contribution to journalArticlepeer-review


This work describes the synthesis, structural characterization and antibacterial activities of 1,3,5-triazacyclohexane type of new compound 1,3-bis-butyl-5-(4-iodophenyl)-1,3,5-triazacyclohexane. The new triazacyclohexanes (R3TAC) with mixed aryl and alkyl N-substituents are synthesized by the reaction of a 1:2 mixture of 4-iodoaniline and n-butylamine with formalin. The synthesized compounds were characterized by spectral analysis IR, 1H NMR and 13C NMR. The compound was screened for it’s antibacterial activity against Gram-positive and Gram-negative bacteria by the diffusion method on agar medium.
Original languageEnglish
Pages (from-to)82-84
JournalCentral European Journal of Chemistry
Issue number1
Publication statusPublished - 31 Mar 2017


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