Synergistically activated dual-locked fluorescent probes to monitor H2S-induced DNA damage

Yafu Wang, Xiaoli Zhao, Yuehua Chen, Tony D. James, Ge Wang, Hua Zhang

Research output: Contribution to journalArticlepeer-review

3 Citations (SciVal)
25 Downloads (Pure)


Naphthalimide-based fluorescent probes (NAN0-N3 and NAN6-N3) were developed with dual locked fluorescence. Here, ≥1.9 × 10−2 mM of H2S and ≥2.2 × 10−2 μg mL−1 of DNA could unlock a highly sensitive off-on fluorescence response through synergistic changes of the molecular structure and conformation. As such, the probes could monitor DNA damage induced by the overexpression of H2S, and were able to evaluate the degree of apoptosis of living cells mediated by H2S-induced mtDNA or nDNA damage.

Original languageEnglish
Pages (from-to)10500-10503
Number of pages4
JournalChemical Communications
Issue number58
Early online date31 Aug 2022
Publication statusPublished - 25 Sept 2022

Bibliographical note

This work was supported by the National Natural Science Foundation of China (U21A20314, 22107089, 21722501); T. D. J. wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01). T. D. J. has been appointed as an Outstanding Talent by Henan Normal University.

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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